Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Delaware State (361) | 51 | 111 | Wake Forest (70) | Final | W | 60 |
| 2 | 2020-11-26 | Alabama State (339) | Wake Forest (115) | Cancelled | - | - | ||
| 3 | 2020-11-27 | Longwood (269) | 60 | 71 | Wake Forest (70) | Final | W | 11 |
| 4 | 2020-12-02 | Troy (127) | 0 | 0 | Wake Forest (70) | Cancelled | - | - |
| 5 | 2020-12-13 | Presbyterian (264) | 0 | 0 | Wake Forest (70) | Cancelled | - | - |
| 6 | 2020-12-13 | Presbyterian (289) | Wake Forest (60) | Cancelled | - | - | ||
| 7 | 2020-12-16 | Virginia (14) | 0 | 0 | Wake Forest (70) | Cancelled | - | - |
| 8 | 2020-12-21 | Virginia Military (157) | Wake Forest (57) | Cancelled | - | - | ||
| 9 | 2020-12-30 | Syracuse (84) | 0 | 0 | Wake Forest (70) | Cancelled | - | - |
| 10 | 2020-12-31 | Catawba | 62 | 70 | Wake Forest (70) | Final | W | 8 |
| 11 | 2021-01-03 | Wake Forest (70) | 54 | 70 | Georgia Tech (158) | Final | L | -16 |
| 12 | 2021-01-06 | Wake Forest (70) | 61 | 70 | Virginia (14) | Final | L | -9 |
| 13 | 2021-01-09 | Wake Forest (70) | 68 | 79 | Duke (3) | Final | L | -11 |
| 14 | 2021-01-13 | Louisville (21) | 77 | 65 | Wake Forest (70) | Final | L | -12 |
| 15 | 2021-01-17 | Virginia Tech (56) | 64 | 60 | Wake Forest (70) | Final | L | -4 |
| 16 | 2021-01-20 | Wake Forest (70) | 73 | 80 | North Carolina (22) | Final | L | -7 |
| 17 | 2021-01-23 | Pittsburgh (108) | 75 | 76 | Wake Forest (70) | Final | W | 1 |
| 18 | 2021-01-27 | Wake Forest (70) | 67 | 72 | North Carolina State (44) | Final | L | -5 |
| 19 | 2021-01-30 | Miami (27) | 54 | 66 | Wake Forest (70) | Final | W | 12 |
| 20 | 2021-02-02 | Wake Forest (70) | 58 | 79 | Notre Dame (101) | Final | L | -21 |
| 21 | 2021-02-10 | Wake Forest (70) | 69 | 65 | Boston College (151) | Final | W | 4 |
| 22 | 2021-02-13 | Wake Forest (70) | 85 | 92 | Florida State (64) | Final/OT | L | -7 |
| 23 | 2021-02-17 | Duke (3) | 84 | 60 | Wake Forest (70) | Final | L | -24 |
| 24 | 2021-02-20 | North Carolina State (44) | 80 | 62 | Wake Forest (70) | Final | L | -18 |
| 25 | 2021-02-24 | Clemson (36) | 60 | 39 | Wake Forest (70) | Final | L | -21 |
| 26 | 2021-02-27 | Wake Forest (70) | 46 | 84 | Virginia Tech (56) | Final | L | -38 |
| 27 | 2021-03-02 | Wake Forest (70) | 57 | 70 | Pittsburgh (108) | Final | L | -13 |
| 28 | 2021-03-03 | Western Carolina (223) | 0 | 0 | Wake Forest (70) | Cancelled | - | - |
| 29 | 2021-03-05 | Georgia Tech (158) | 75 | 63 | Wake Forest (70) | Final | L | -12 |
| 30 | 2021-03-09 | Wake Forest (70) | 77 | 80 | Notre Dame (101) | Final | L | -3 |