Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Virginia (22) | Maine (316) | Cancelled | - | - | ||
| 2 | 2020-11-25 | Towson (152) | 54 | 89 | Virginia (14) | Final | W | 35 |
| 3 | 2020-11-25 | Virginia (22) | 89 | 54 | Towson (162) | Final | W | 35 |
| 4 | 2020-11-27 | Virginia (22) | Florida (38) | Cancelled | - | - | ||
| 5 | 2020-11-27 | South Florida (124) | Virginia (22) | Cancelled | - | - | ||
| 6 | 2020-11-27 | Virginia (14) | 60 | 61 | San Francisco (122) | Final | L | -1 |
| 7 | 2020-12-01 | St. Francis (PA) (234) | 51 | 76 | Virginia (253) | Final | W | 25 |
| 8 | 2020-12-04 | Kent State (107) | 64 | 71 | Virginia (14) | Final/OT | W | 7 |
| 9 | 2020-12-09 | Michigan State (10) | 0 | 0 | Virginia (14) | Cancelled | - | - |
| 10 | 2020-12-13 | William & Mary (141) | 0 | 0 | Virginia (14) | Postponed | - | - |
| 11 | 2020-12-16 | Virginia (14) | 0 | 0 | Wake Forest (70) | Cancelled | - | - |
| 12 | 2020-12-19 | Villanova (15) | Virginia (64) | Cancelled | - | - | ||
| 13 | 2020-12-22 | William & Mary (141) | 40 | 76 | Virginia (14) | Final | W | 36 |
| 14 | 2020-12-26 | Virginia (14) | 75 | 98 | Gonzaga (11) | Final | L | -23 |
| 15 | 2020-12-30 | Virginia (14) | 66 | 57 | Notre Dame (101) | Final | W | 9 |
| 16 | 2021-01-02 | Virginia Tech (56) | 0 | 0 | Virginia (14) | Cancelled | - | - |
| 17 | 2021-01-06 | Wake Forest (70) | 61 | 70 | Virginia (14) | Final | W | 9 |
| 18 | 2021-01-09 | Virginia (14) | 61 | 49 | Boston College (151) | Final | W | 12 |
| 19 | 2021-01-13 | Notre Dame (101) | 68 | 80 | Virginia (14) | Final | W | 12 |
| 20 | 2021-01-16 | Virginia (14) | 85 | 50 | Clemson (36) | Final | W | 35 |
| 21 | 2021-01-20 | North Carolina State (44) | 0 | 0 | Virginia (14) | Postponed | - | - |
| 22 | 2021-01-23 | Georgia Tech (158) | 62 | 64 | Virginia (14) | Final | W | 2 |
| 23 | 2021-01-25 | Syracuse (84) | 58 | 81 | Virginia (14) | Final | W | 23 |
| 24 | 2021-01-30 | Virginia (14) | 51 | 65 | Virginia Tech (56) | Final | L | -14 |
| 25 | 2021-02-03 | Virginia (14) | 64 | 57 | North Carolina State (44) | Final | W | 7 |
| 26 | 2021-02-06 | Louisville (40) | 0 | 0 | Virginia (15) | Cancelled | - | - |
| 27 | 2021-02-06 | Pittsburgh (108) | 66 | 73 | Virginia (14) | Final | W | 7 |
| 28 | 2021-02-10 | Virginia (14) | 57 | 49 | Georgia Tech (158) | Final | W | 8 |
| 29 | 2021-02-13 | North Carolina (22) | 48 | 60 | Virginia (14) | Final | W | 12 |
| 30 | 2021-02-15 | Virginia (14) | 60 | 81 | Florida State (64) | Final | L | -21 |
| 31 | 2021-02-20 | Virginia (14) | 65 | 66 | Duke (3) | Final | L | -1 |
| 32 | 2021-02-24 | North Carolina State (44) | 68 | 61 | Virginia (14) | Final | L | -7 |
| 33 | 2021-03-01 | Miami (166) | 51 | 62 | Virginia (27) | Final | W | 11 |
| 34 | 2021-03-06 | Virginia (14) | 68 | 58 | Louisville (21) | Final | W | 10 |
| 35 | 2021-03-11 | Syracuse (84) | 69 | 72 | Virginia (14) | Final | W | 3 |
| 36 | 2021-03-12 | Georgia Tech (158) | 1 | 0 | Virginia (14) | Cancelled | L | -1 |
| 37 | 2021-03-12 | Georgia Tech (42) | 0 | 0 | Virginia (24) | Cancelled | - | - |
| 38 | 2021-03-20 | Ohio (95) | 62 | 58 | Virginia (18) | Final | L | -4 |