Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Gardner-Webb (363) | 0 | 0 | Duke (3) | Postponed | - | - |
| 2 | 2020-11-28 | Coppin State (360) | 71 | 81 | Duke (3) | Final | W | 10 |
| 3 | 2020-12-01 | Michigan State (10) | 75 | 69 | Duke (3) | Final | L | -6 |
| 4 | 2020-12-04 | Bellarmine (266) | 54 | 76 | Duke (3) | Final | W | 22 |
| 5 | 2020-12-06 | Elon (232) | 0 | 0 | Duke (3) | Cancelled | - | - |
| 6 | 2020-12-08 | Illinois (9) | 83 | 68 | Duke (3) | Final | L | -15 |
| 7 | 2020-12-12 | Charleston Southern (262) | 0 | 0 | Duke (3) | Cancelled | - | - |
| 8 | 2020-12-16 | Duke (3) | 75 | 65 | Notre Dame (101) | Final | W | 10 |
| 9 | 2020-12-19 | Gardner-Webb (363) | 0 | 0 | Duke (3) | Cancelled | - | - |
| 10 | 2020-12-29 | Pittsburgh (108) | 0 | 0 | Duke (3) | Cancelled | - | - |
| 11 | 2021-01-02 | Duke (3) | 0 | 0 | Florida State (64) | Cancelled | - | - |
| 12 | 2021-01-06 | Boston College (151) | 82 | 83 | Duke (3) | Final | W | 1 |
| 13 | 2021-01-09 | Wake Forest (70) | 68 | 79 | Duke (3) | Final | W | 11 |
| 14 | 2021-01-12 | Duke (3) | 67 | 74 | Virginia Tech (56) | Final | L | -7 |
| 15 | 2021-01-19 | Duke (3) | 73 | 79 | Pittsburgh (108) | Final | L | -6 |
| 16 | 2021-01-23 | Duke (3) | 65 | 70 | Louisville (21) | Final | L | -5 |
| 17 | 2021-01-26 | Georgia Tech (158) | 68 | 75 | Duke (3) | Final | W | 7 |
| 18 | 2021-01-30 | Clemson (36) | 53 | 79 | Duke (3) | Final | W | 26 |
| 19 | 2021-02-01 | Duke (3) | 75 | 77 | Miami (27) | Final | L | -2 |
| 20 | 2021-02-06 | North Carolina (22) | 91 | 87 | Duke (3) | Final | L | -4 |
| 21 | 2021-02-09 | Notre Dame (101) | 93 | 89 | Duke (3) | Final | L | -4 |
| 22 | 2021-02-13 | Duke (3) | 69 | 53 | North Carolina State (44) | Final | W | 16 |
| 23 | 2021-02-17 | Duke (3) | 84 | 60 | Wake Forest (70) | Final | W | 24 |
| 24 | 2021-02-20 | Virginia (14) | 65 | 66 | Duke (3) | Final | W | 1 |
| 25 | 2021-02-22 | Syracuse (84) | 71 | 85 | Duke (3) | Final | W | 14 |
| 26 | 2021-02-27 | Louisville (21) | 80 | 73 | Duke (3) | Final/OT | L | -7 |
| 27 | 2021-03-02 | Duke (3) | 77 | 81 | Georgia Tech (158) | Final/OT | L | -4 |
| 28 | 2021-03-06 | Duke (3) | 73 | 91 | North Carolina (22) | Final | L | -18 |
| 29 | 2021-03-09 | Boston College (151) | 51 | 86 | Duke (3) | Final | W | 35 |
| 30 | 2021-03-10 | Duke (69) | 70 | 56 | Louisville (46) | Final | W | 14 |
| 31 | 2021-03-11 | Duke (3) | 0 | 1 | Florida State (64) | Cancelled | L | -1 |
| 32 | 2021-03-11 | Duke (69) | 0 | 0 | Florida State (20) | Cancelled | - | - |