Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | UMBC (198) | 62 | 70 | Georgetown (83) | Final | W | 8 |
| 2 | 2020-12-01 | Navy (149) | 78 | 71 | Georgetown (83) | Final | L | -7 |
| 3 | 2020-12-06 | West Virginia (50) | 80 | 71 | Georgetown (83) | Final | L | -9 |
| 4 | 2020-12-08 | Coppin State (360) | 48 | 80 | Georgetown (83) | Final | W | 32 |
| 5 | 2020-12-11 | Villanova (29) | 76 | 63 | Georgetown (83) | Final | L | -13 |
| 6 | 2020-12-13 | Connecticut (4) | 0 | 0 | Georgetown (83) | Cancelled | - | - |
| 7 | 2020-12-13 | St. John's (12) | 94 | 97 | Georgetown (83) | Final/OT | W | 3 |
| 8 | 2020-12-20 | Georgetown (83) | 83 | 94 | St. John's (12) | Final | L | -11 |
| 9 | 2020-12-23 | Georgetown (83) | 67 | 78 | Seton Hall (53) | Final | L | -11 |
| 10 | 2021-01-02 | Marquette (106) | 64 | 60 | Georgetown (83) | Final | L | -4 |
| 11 | 2021-01-06 | Georgetown (83) | 55 | 63 | Butler (80) | Final | L | -8 |
| 12 | 2021-01-09 | Georgetown (83) | 69 | 74 | Syracuse (84) | Final | L | -5 |
| 13 | 2021-01-13 | DePaul (95) | 0 | 0 | Georgetown (83) | Cancelled | - | - |
| 14 | 2021-01-16 | Georgetown (83) | 0 | 0 | Providence (82) | Cancelled | - | - |
| 15 | 2021-01-20 | Georgetown (83) | 0 | 0 | Marquette (106) | Cancelled | - | - |
| 16 | 2021-01-26 | Georgetown (83) | 0 | 0 | Xavier (92) | Cancelled | - | - |
| 17 | 2021-01-30 | Providence (82) | 72 | 73 | Georgetown (83) | Final | W | 1 |
| 18 | 2021-02-03 | Georgetown (83) | 86 | 79 | Creighton (78) | Final | W | 7 |
| 19 | 2021-02-07 | Georgetown (83) | 74 | 84 | Villanova (29) | Final | L | -10 |
| 20 | 2021-02-09 | Creighton (78) | 63 | 48 | Georgetown (83) | Final | L | -15 |
| 21 | 2021-02-13 | Butler (80) | 63 | 78 | Georgetown (83) | Final | W | 15 |
| 22 | 2021-02-20 | Seton Hall (53) | 75 | 81 | Georgetown (83) | Final | W | 6 |
| 23 | 2021-02-23 | Connecticut (4) | 70 | 57 | Georgetown (83) | Final | L | -13 |
| 24 | 2021-02-27 | Georgetown (83) | 68 | 60 | DePaul (95) | Final | W | 8 |
| 25 | 2021-03-02 | Xavier (92) | 66 | 72 | Georgetown (83) | Final | W | 6 |
| 26 | 2021-03-06 | Georgetown (83) | 82 | 98 | Connecticut (4) | Final | L | -16 |
| 27 | 2021-03-10 | Marquette (79) | 49 | 68 | Georgetown (93) | Final | W | 19 |
| 28 | 2021-03-11 | Georgetown (83) | 72 | 71 | Villanova (29) | Final | W | 1 |
| 29 | 2021-03-12 | Georgetown (83) | 66 | 58 | Seton Hall (53) | Final | W | 8 |
| 30 | 2021-03-13 | Georgetown (93) | 73 | 48 | Creighton (27) | Final | W | 25 |
| 31 | 2021-03-20 | Georgetown (63) | 73 | 96 | Colorado (23) | Final | L | -23 |