Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-28 | Notre Dame (101) | 70 | 80 | Michigan State (10) | Final | L | -10 |
| 2 | 2020-12-02 | Western Michigan (304) | 0 | 0 | Notre Dame (101) | Cancelled | - | - |
| 3 | 2020-12-02 | Western Michigan (280) | Notre Dame (272) | Cancelled | - | - | ||
| 4 | 2020-12-04 | Tennessee (18) | 0 | 0 | Notre Dame (101) | Cancelled | - | - |
| 5 | 2020-12-04 | Tennessee (220) | Notre Dame (272) | Cancelled | - | - | ||
| 6 | 2020-12-05 | Purdue Fort Wayne (95) | Notre Dame (272) | Cancelled | - | - | ||
| 7 | 2020-12-06 | Detroit (212) | 70 | 78 | Notre Dame (101) | Final | W | 8 |
| 8 | 2020-12-08 | Ohio State (34) | 90 | 85 | Notre Dame (101) | Final | L | -5 |
| 9 | 2020-12-12 | Notre Dame (101) | 64 | 63 | Kentucky (26) | Final | W | 1 |
| 10 | 2020-12-16 | Duke (3) | 75 | 65 | Notre Dame (101) | Final | L | -10 |
| 11 | 2020-12-19 | Notre Dame (101) | 78 | 88 | Purdue (8) | Final | L | -10 |
| 12 | 2020-12-19 | Purdue (70) | 88 | 78 | Notre Dame (125) | Final | L | -10 |
| 13 | 2020-12-22 | Notre Dame (101) | 0 | 0 | Syracuse (84) | Postponed | - | - |
| 14 | 2020-12-23 | Bellarmine (266) | 70 | 81 | Notre Dame (101) | Final | W | 11 |
| 15 | 2020-12-30 | Virginia (14) | 66 | 57 | Notre Dame (101) | Final | L | -9 |
| 16 | 2021-01-02 | Notre Dame (198) | 0 | 0 | Pittsburgh (70) | Cancelled | - | - |
| 17 | 2021-01-02 | Notre Dame (101) | 65 | 66 | North Carolina (22) | Final | L | -1 |
| 18 | 2021-01-06 | Western Michigan (304) | 0 | 0 | Notre Dame (101) | Cancelled | - | - |
| 19 | 2021-01-06 | Georgia Tech (84) | 0 | 0 | Notre Dame (198) | Cancelled | - | - |
| 20 | 2021-01-10 | Notre Dame (101) | 63 | 77 | Virginia Tech (56) | Final | L | -14 |
| 21 | 2021-01-13 | Notre Dame (101) | 68 | 80 | Virginia (14) | Final | L | -12 |
| 22 | 2021-01-16 | Boston College (151) | 70 | 80 | Notre Dame (101) | Final | W | 10 |
| 23 | 2021-01-18 | Notre Dame (101) | 0 | 0 | Howard (211) | Cancelled | - | - |
| 24 | 2021-01-24 | Notre Dame (101) | 73 | 59 | Miami (27) | Final | W | 14 |
| 25 | 2021-01-27 | Virginia Tech (56) | 62 | 51 | Notre Dame (101) | Final | L | -11 |
| 26 | 2021-01-30 | Notre Dame | 0 | 0 | North Carolina | Cancelled | - | - |
| 27 | 2021-01-30 | Notre Dame (125) | 84 | 58 | Pittsburgh (60) | Final | W | 26 |
| 28 | 2021-01-31 | Notre Dame (101) | 84 | 58 | Pittsburgh (108) | Final | W | 26 |
| 29 | 2021-02-02 | Wake Forest (70) | 58 | 79 | Notre Dame (101) | Final | W | 21 |
| 30 | 2021-02-06 | Notre Dame (101) | 80 | 82 | Georgia Tech (158) | Final | L | -2 |
| 31 | 2021-02-09 | Notre Dame (101) | 93 | 89 | Duke (3) | Final | W | 4 |
| 32 | 2021-02-14 | Miami (27) | 61 | 71 | Notre Dame (101) | Final | W | 10 |
| 33 | 2021-02-17 | Clemson (36) | 0 | 0 | Notre Dame (101) | Cancelled | - | - |
| 34 | 2021-02-20 | Notre Dame (101) | 67 | 75 | Syracuse (84) | Final | L | -8 |
| 35 | 2021-02-23 | Notre Dame (101) | 57 | 69 | Louisville (21) | Final | L | -12 |
| 36 | 2021-02-27 | Notre Dame (101) | 90 | 94 | Boston College (151) | Final | L | -4 |
| 37 | 2021-03-03 | North Carolina State (44) | 80 | 69 | Notre Dame (101) | Final | L | -11 |
| 38 | 2021-03-06 | Florida State (64) | 73 | 83 | Notre Dame (101) | Final | W | 10 |
| 39 | 2021-03-09 | Wake Forest (70) | 77 | 80 | Notre Dame (101) | Final | W | 3 |
| 40 | 2021-03-10 | Notre Dame (99) | 59 | 101 | North Carolina (40) | Final | L | -42 |