Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Lamar (279) | 45 | 89 | Houston (5) | Final | W | 44 |
| 2 | 2020-11-27 | Boise State (62) | 58 | 68 | Houston (5) | Final | W | 10 |
| 3 | 2020-11-29 | Texas Tech (20) | 53 | 64 | Houston (5) | Final | W | 11 |
| 4 | 2020-12-05 | South Carolina (110) | 67 | 77 | Houston (5) | Final | W | 10 |
| 5 | 2020-12-09 | Sam Houston State (120) | 0 | 0 | Houston (5) | Cancelled | - | - |
| 6 | 2020-12-12 | Rice (228) | 0 | 0 | Houston (5) | Cancelled | - | - |
| 7 | 2020-12-15 | Central Florida (43) | 0 | 0 | Houston (5) | Postponed | - | - |
| 8 | 2020-12-19 | Houston (4) | Alabama (77) | Cancelled | - | - | ||
| 9 | 2020-12-20 | Alcorn State (348) | 55 | 88 | Houston (5) | Final | W | 33 |
| 10 | 2020-12-22 | Temple (169) | 50 | 76 | Houston (5) | Final | W | 26 |
| 11 | 2020-12-26 | Houston (5) | 63 | 54 | Central Florida (43) | Final | W | 9 |
| 12 | 2020-12-29 | Houston (5) | 64 | 65 | Tulsa (55) | Final | L | -1 |
| 13 | 2021-01-03 | Houston (5) | 74 | 60 | SMU (45) | Final | W | 14 |
| 14 | 2021-01-06 | Wichita State (76) | 63 | 70 | Houston (5) | Final | W | 7 |
| 15 | 2021-01-09 | Tulane (167) | 50 | 71 | Houston (5) | Final | W | 21 |
| 16 | 2021-01-14 | Houston (5) | 0 | 0 | South Florida (52) | Postponed | - | - |
| 17 | 2021-01-17 | Central Florida (43) | 58 | 75 | Houston (5) | Final | W | 17 |
| 18 | 2021-01-20 | Tulsa (55) | 59 | 86 | Houston (5) | Final | W | 27 |
| 19 | 2021-01-23 | Cincinnati (132) | 0 | 0 | Houston (5) | Cancelled | - | - |
| 20 | 2021-01-23 | Houston (5) | 68 | 51 | Temple (169) | Final | W | 17 |
| 21 | 2021-01-28 | Houston (5) | 83 | 60 | Tulane (167) | Final | W | 23 |
| 22 | 2021-01-31 | SMU (45) | 48 | 70 | Houston (5) | Final | W | 22 |
| 23 | 2021-02-03 | Houston (5) | 73 | 82 | East Carolina (252) | Final | L | -9 |
| 24 | 2021-02-06 | Lady of the Lake | 46 | 112 | Houston (5) | Final | W | 66 |
| 25 | 2021-02-10 | Houston (5) | 82 | 65 | South Florida (52) | Final | W | 17 |
| 26 | 2021-02-14 | Memphis (136) | 0 | 0 | Houston (5) | Postponed | - | - |
| 27 | 2021-02-17 | East Carolina (252) | 0 | 0 | Houston (5) | Cancelled | - | - |
| 28 | 2021-02-18 | Houston (5) | 63 | 68 | Wichita State (76) | Final | L | -5 |
| 29 | 2021-02-21 | Cincinnati (54) | 52 | 90 | Houston (5) | Final | W | 38 |
| 30 | 2021-02-25 | Western Kentucky (154) | 57 | 81 | Houston (5) | Final | W | 24 |
| 31 | 2021-02-28 | South Florida (52) | 52 | 98 | Houston (5) | Final | W | 46 |
| 32 | 2021-03-07 | Memphis (136) | 64 | 67 | Houston (5) | Final | W | 3 |
| 33 | 2021-03-12 | Tulane (167) | 52 | 77 | Houston (5) | Final | W | 25 |
| 34 | 2021-03-13 | Memphis (49) | 74 | 76 | Houston (5) | Final | W | 2 |
| 35 | 2021-03-14 | Cincinnati (54) | 54 | 91 | Houston (5) | Final | W | 37 |
| 36 | 2021-03-19 | Cleveland State (139) | 56 | 87 | Houston (5) | Final | W | 31 |
| 37 | 2021-03-21 | Rutgers (35) | 60 | 63 | Houston (5) | Final | W | 3 |
| 38 | 2021-03-27 | Syracuse (45) | 46 | 62 | Houston (5) | Final | W | 16 |
| 39 | 2021-03-29 | Oregon State (69) | 61 | 67 | Houston (5) | Final | W | 6 |
| 40 | 2021-04-03 | Houston (5) | 59 | 78 | Baylor (2) | Final | L | -19 |