Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Evansville (302) | 44 | 79 | Louisville (21) | Final | W | 35 |
| 2 | 2020-11-27 | Seton Hall (53) | 70 | 71 | Louisville (21) | Final | W | 1 |
| 3 | 2020-11-29 | Prairie View A&M (285) | 64 | 86 | Louisville (21) | Final | W | 22 |
| 4 | 2020-12-01 | Western Kentucky (154) | 54 | 75 | Louisville (21) | Final | W | 21 |
| 5 | 2020-12-04 | UNC-Greensboro (265) | 0 | 0 | Louisville (21) | Cancelled | - | - |
| 6 | 2020-12-04 | UNC-Greensboro (53) | Louisville (15) | Cancelled | - | - | ||
| 7 | 2020-12-09 | Louisville (12) | 0 | 0 | Wisconsin (80) | Cancelled | - | - |
| 8 | 2020-12-16 | North Carolina State (44) | 0 | 0 | Louisville (21) | Cancelled | - | - |
| 9 | 2020-12-19 | Louisville (21) | 48 | 85 | Wisconsin (24) | Final | L | -37 |
| 10 | 2020-12-22 | Louisville (21) | 64 | 54 | Pittsburgh (108) | Final | W | 10 |
| 11 | 2020-12-26 | Kentucky (26) | 59 | 62 | Louisville (21) | Final | W | 3 |
| 12 | 2021-01-02 | Louisville (21) | 76 | 64 | Boston College (151) | Final | W | 12 |
| 13 | 2021-01-06 | Virginia Tech (56) | 71 | 73 | Louisville (21) | Final | W | 2 |
| 14 | 2021-01-09 | Georgia Tech (158) | 0 | 0 | Louisville (21) | Postponed | - | - |
| 15 | 2021-01-13 | Louisville (21) | 77 | 65 | Wake Forest (70) | Final | W | 12 |
| 16 | 2021-01-16 | Louisville (21) | 72 | 78 | Miami (27) | Final | L | -6 |
| 17 | 2021-01-18 | Florida State (64) | 78 | 65 | Louisville (21) | Final | L | -13 |
| 18 | 2021-01-23 | Duke (3) | 65 | 70 | Louisville (21) | Final | W | 5 |
| 19 | 2021-01-27 | Louisville (21) | 50 | 54 | Clemson (36) | Final | L | -4 |
| 20 | 2021-01-30 | Boston College (151) | 0 | 0 | Louisville (21) | Cancelled | - | - |
| 21 | 2021-02-01 | Georgia Tech (158) | 58 | 74 | Louisville (21) | Final | W | 16 |
| 22 | 2021-02-03 | Louisville (21) | 0 | 0 | Syracuse (84) | Cancelled | - | - |
| 23 | 2021-02-06 | Louisville (40) | 0 | 0 | Virginia (15) | Cancelled | - | - |
| 24 | 2021-02-10 | Pittsburgh (108) | 0 | 0 | Louisville (21) | Cancelled | - | - |
| 25 | 2021-02-13 | Louisville (21) | 0 | 0 | Virginia Tech (56) | Cancelled | - | - |
| 26 | 2021-02-17 | Syracuse (84) | 0 | 0 | Louisville (21) | Cancelled | - | - |
| 27 | 2021-02-20 | Louisville (21) | 54 | 99 | North Carolina (22) | Final | L | -45 |
| 28 | 2021-02-23 | Notre Dame (101) | 57 | 69 | Louisville (21) | Final | W | 12 |
| 29 | 2021-02-27 | Louisville (21) | 80 | 73 | Duke (3) | Final/OT | W | 7 |
| 30 | 2021-03-03 | Louisville (21) | 0 | 0 | Virginia Tech (56) | Cancelled | - | - |
| 31 | 2021-03-06 | Virginia (14) | 68 | 58 | Louisville (21) | Final | L | -10 |
| 32 | 2021-03-10 | Duke (69) | 70 | 56 | Louisville (46) | Final | L | -14 |