Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Eastern Michigan (277) | 67 | 83 | Michigan State (10) | Final | W | 16 |
| 2 | 2020-11-28 | Notre Dame (101) | 70 | 80 | Michigan State (10) | Final | W | 10 |
| 3 | 2020-12-01 | Michigan State (10) | 75 | 69 | Duke (3) | Final | W | 6 |
| 4 | 2020-12-04 | Detroit (212) | 76 | 83 | Michigan State (10) | Final | W | 7 |
| 5 | 2020-12-06 | Western Michigan (304) | 61 | 79 | Michigan State (10) | Final | W | 18 |
| 6 | 2020-12-09 | Michigan State (10) | 0 | 0 | Virginia (14) | Cancelled | - | - |
| 7 | 2020-12-13 | Oakland (172) | 91 | 109 | Michigan State (10) | Final | W | 18 |
| 8 | 2020-12-20 | Michigan State (10) | 65 | 79 | Northwestern (75) | Final | L | -14 |
| 9 | 2020-12-25 | Wisconsin (22) | 85 | 76 | Michigan State (68) | Final | L | -9 |
| 10 | 2020-12-28 | Michigan State (10) | 56 | 81 | Minnesota (87) | Final | L | -25 |
| 11 | 2021-01-02 | Michigan State (10) | 84 | 77 | Nebraska (13) | Final | W | 7 |
| 12 | 2021-01-05 | Rutgers (112) | 45 | 68 | Michigan State (10) | Final | W | 23 |
| 13 | 2021-01-08 | Purdue (8) | 55 | 54 | Michigan State (10) | Final | L | -1 |
| 14 | 2021-01-14 | Michigan State (10) | 0 | 0 | Iowa (28) | Postponed | - | - |
| 15 | 2021-01-17 | Indiana (46) | 0 | 0 | Michigan State (10) | Postponed | - | - |
| 16 | 2021-01-23 | Illinois (9) | 0 | 0 | Michigan State (10) | Postponed | - | - |
| 17 | 2021-01-28 | Michigan State (10) | 37 | 67 | Rutgers (112) | Final | L | -30 |
| 18 | 2021-01-31 | Michigan State (10) | 62 | 79 | Ohio State (34) | Final | L | -17 |
| 19 | 2021-02-02 | Michigan State (10) | 78 | 84 | Iowa (28) | Final | L | -6 |
| 20 | 2021-02-06 | Michigan State (81) | 0 | 0 | Michigan (4) | Cancelled | - | - |
| 21 | 2021-02-06 | Nebraska (13) | 56 | 66 | Michigan State (10) | Final | W | 10 |
| 22 | 2021-02-09 | Penn State (129) | 58 | 60 | Michigan State (10) | Final | W | 2 |
| 23 | 2021-02-13 | Iowa (28) | 88 | 58 | Michigan State (10) | Final | L | -30 |
| 24 | 2021-02-16 | Michigan State (10) | 65 | 75 | Purdue (8) | Final | L | -10 |
| 25 | 2021-02-20 | Michigan State (10) | 78 | 71 | Indiana (46) | Final | W | 7 |
| 26 | 2021-02-23 | Illinois (9) | 72 | 81 | Michigan State (10) | Final | W | 9 |
| 27 | 2021-02-25 | Ohio State (34) | 67 | 71 | Michigan State (10) | Final | W | 4 |
| 28 | 2021-02-28 | Michigan State (10) | 55 | 73 | Maryland (114) | Final | L | -18 |
| 29 | 2021-03-02 | Indiana (46) | 58 | 64 | Michigan State (10) | Final | W | 6 |
| 30 | 2021-03-04 | Michigan State (10) | 50 | 69 | Michigan (1) | Final | L | -19 |
| 31 | 2021-03-07 | Michigan (1) | 64 | 70 | Michigan State (10) | Final | W | 6 |
| 32 | 2021-03-11 | Michigan State (10) | 57 | 68 | Maryland (114) | Final | L | -11 |
| 33 | 2021-03-18 | UCLA (42) | 86 | 80 | Michigan State (55) | Final (OT) | L | -6 |