Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Charlotte (173) | 0 | 0 | Tennessee (18) | Cancelled | - | - |
| 2 | 2020-11-25 | Charlotte (170) | Tennessee (59) | Cancelled | - | - | ||
| 3 | 2020-11-27 | Virginia Commonwealth (83) | Tennessee (59) | Cancelled | - | - | ||
| 4 | 2020-12-04 | Tennessee (18) | 0 | 0 | Notre Dame (101) | Cancelled | - | - |
| 5 | 2020-12-04 | Tennessee (220) | Gonzaga (9) | Cancelled | - | - | ||
| 6 | 2020-12-04 | Tennessee (220) | Notre Dame (272) | Cancelled | - | - | ||
| 7 | 2020-12-08 | Colorado (73) | 47 | 56 | Tennessee (18) | Final | W | 9 |
| 8 | 2020-12-09 | Tennessee-Martin (205) | 0 | 0 | Tennessee (18) | Cancelled | - | - |
| 9 | 2020-12-12 | Cincinnati (54) | 56 | 65 | Tennessee (18) | Final | W | 9 |
| 10 | 2020-12-15 | Appalachian State (159) | 38 | 79 | Tennessee (18) | Final | W | 41 |
| 11 | 2020-12-18 | Tennessee Tech (310) | 49 | 103 | Tennessee (18) | Final | W | 54 |
| 12 | 2020-12-21 | Saint Joseph's (99) | 66 | 102 | Tennessee (18) | Final | W | 36 |
| 13 | 2020-12-23 | South Carolina Upstate (293) | 60 | 80 | Tennessee (18) | Final | W | 20 |
| 14 | 2020-12-30 | Tennessee (18) | 73 | 53 | Missouri (51) | Final | W | 20 |
| 15 | 2021-01-02 | Alabama (15) | 71 | 63 | Tennessee (18) | Final | L | -8 |
| 16 | 2021-01-06 | Arkansas (16) | 74 | 79 | Tennessee (18) | Final | W | 5 |
| 17 | 2021-01-09 | Tennessee (18) | 68 | 54 | Texas A&M (39) | Final | W | 14 |
| 18 | 2021-01-12 | Tennessee (6) | 0 | 0 | South Carolina (74) | Cancelled | - | - |
| 19 | 2021-01-12 | Tennessee (18) | 0 | 0 | Vanderbilt (17) | Postponed | - | - |
| 20 | 2021-01-16 | Vanderbilt (17) | 61 | 81 | Tennessee (18) | Final | W | 20 |
| 21 | 2021-01-19 | Tennessee (18) | 49 | 75 | Florida (6) | Final | L | -26 |
| 22 | 2021-01-23 | Missouri (51) | 73 | 64 | Tennessee (18) | Final | L | -9 |
| 23 | 2021-01-26 | Mississippi State (100) | 53 | 56 | Tennessee (18) | Final | W | 3 |
| 24 | 2021-01-30 | Kansas (19) | 61 | 80 | Tennessee (18) | Final | W | 19 |
| 25 | 2021-02-02 | Tennessee (18) | 50 | 52 | Ole Miss (79) | Final | L | -2 |
| 26 | 2021-02-06 | Tennessee (18) | 82 | 71 | Kentucky (26) | Final | W | 11 |
| 27 | 2021-02-10 | Florida (38) | 0 | 0 | Tennessee (12) | Cancelled | - | - |
| 28 | 2021-02-10 | Georgia (35) | 81 | 89 | Tennessee (18) | Final | W | 8 |
| 29 | 2021-02-13 | Tennessee (18) | 65 | 78 | LSU (77) | Final | L | -13 |
| 30 | 2021-02-17 | South Carolina (110) | 73 | 93 | Tennessee (18) | Final | W | 20 |
| 31 | 2021-02-20 | Kentucky (26) | 70 | 55 | Tennessee (18) | Final | L | -15 |
| 32 | 2021-02-24 | Tennessee (18) | 70 | 58 | Vanderbilt (17) | Final | W | 12 |
| 33 | 2021-02-27 | Tennessee (18) | 72 | 77 | Auburn (37) | Final | L | -5 |
| 34 | 2021-03-07 | Florida (6) | 54 | 65 | Tennessee (18) | Final | W | 11 |
| 35 | 2021-03-12 | Florida (6) | 66 | 78 | Tennessee (18) | Final | W | 12 |
| 36 | 2021-03-13 | Tennessee (23) | 68 | 73 | Alabama (7) | Final | L | -5 |
| 37 | 2021-03-19 | Oregon State (69) | 70 | 56 | Tennessee (19) | Final | L | -14 |