Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Illinois State (94) | 67 | 94 | Ohio State (34) | Final | W | 27 |
| 2 | 2020-11-29 | UMass-Lowell (319) | 64 | 74 | Ohio State (34) | Final | W | 10 |
| 3 | 2020-12-02 | Morehead State (233) | 44 | 77 | Ohio State (34) | Final | W | 33 |
| 4 | 2020-12-05 | Alabama A&M (286) | 0 | 0 | Ohio State (34) | Cancelled | - | - |
| 5 | 2020-12-05 | Alabama A&M (80) | Ohio State (13) | Cancelled | - | - | ||
| 6 | 2020-12-08 | Ohio State (34) | 90 | 85 | Notre Dame (101) | Final | W | 5 |
| 7 | 2020-12-13 | Cleveland State (308) | 61 | 67 | Ohio State (34) | Final | W | 6 |
| 8 | 2020-12-16 | Ohio State (34) | 60 | 67 | Purdue (8) | Final | L | -7 |
| 9 | 2020-12-19 | Ohio State (28) | North Carolina (59) | Cancelled | - | - | ||
| 10 | 2020-12-19 | UCLA (30) | 70 | 77 | Ohio State (34) | Final | W | 7 |
| 11 | 2020-12-23 | Rutgers (112) | 68 | 80 | Ohio State (34) | Final | W | 12 |
| 12 | 2020-12-26 | Ohio State (34) | 70 | 71 | Northwestern (75) | Final | L | -1 |
| 13 | 2020-12-30 | Nebraska (13) | 54 | 90 | Ohio State (34) | Final | W | 36 |
| 14 | 2021-01-03 | Ohio State (34) | 60 | 77 | Minnesota (87) | Final | L | -17 |
| 15 | 2021-01-06 | Penn State (129) | 0 | 0 | Ohio State (34) | Postponed | - | - |
| 16 | 2021-01-09 | Ohio State (34) | 79 | 68 | Rutgers (112) | Final | W | 11 |
| 17 | 2021-01-13 | Northwestern (75) | 71 | 81 | Ohio State (34) | Final | W | 10 |
| 18 | 2021-01-16 | Ohio State (34) | 87 | 81 | Illinois (9) | Final | W | 6 |
| 19 | 2021-01-19 | Purdue (8) | 67 | 65 | Ohio State (34) | Final | L | -2 |
| 20 | 2021-01-23 | Ohio State (34) | 74 | 62 | Wisconsin (24) | Final | W | 12 |
| 21 | 2021-01-27 | Penn State (129) | 79 | 83 | Ohio State (34) | Final | W | 4 |
| 22 | 2021-01-31 | Michigan State (10) | 62 | 79 | Ohio State (34) | Final | W | 17 |
| 23 | 2021-02-04 | Ohio State (34) | 89 | 85 | Iowa (28) | Final | W | 4 |
| 24 | 2021-02-08 | Ohio State (34) | 73 | 65 | Maryland (114) | Final | W | 8 |
| 25 | 2021-02-13 | Indiana (46) | 59 | 78 | Ohio State (34) | Final | W | 19 |
| 26 | 2021-02-18 | Ohio State (34) | 92 | 82 | Penn State (129) | Final | W | 10 |
| 27 | 2021-02-21 | Michigan (1) | 92 | 87 | Ohio State (34) | Final | L | -5 |
| 28 | 2021-02-25 | Ohio State (34) | 67 | 71 | Michigan State (10) | Final | L | -4 |
| 29 | 2021-02-28 | Iowa (28) | 73 | 57 | Ohio State (34) | Final | L | -16 |
| 30 | 2021-03-06 | Illinois (9) | 73 | 68 | Ohio State (34) | Final | L | -5 |
| 31 | 2021-03-11 | Minnesota (87) | 75 | 79 | Ohio State (34) | Final | W | 4 |
| 32 | 2021-03-12 | Ohio State (34) | 87 | 78 | Purdue (8) | Final/OT | W | 9 |
| 33 | 2021-03-13 | Ohio State (9) | 68 | 67 | Michigan (3) | Final | W | 1 |
| 34 | 2021-03-14 | Ohio State (34) | 88 | 91 | Illinois (9) | Final/OT | L | -3 |
| 35 | 2021-03-19 | Oral Roberts (174) | 75 | 72 | Ohio State (9) | Final (OT) | L | -3 |