Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Southeastern Louisiana (318) | 63 | 67 | Purdue Fort Wayne (222) | Final/OT | W | 4 |
| 2 | 2020-11-30 | Purdue Fort Wayne (222) | 0 | 0 | Kent State (107) | Cancelled | - | - |
| 3 | 2020-12-03 | Adrian | 0 | 0 | Purdue Fort Wayne (222) | Cancelled | - | - |
| 4 | 2020-12-03 | Alcorn State (314) | Purdue Fort Wayne (95) | Cancelled | - | - | ||
| 5 | 2020-12-05 | Purdue Fort Wayne (95) | Notre Dame (272) | Cancelled | - | - | ||
| 6 | 2020-12-08 | Purdue Fort Wayne (124) | Dayton (127) | Cancelled | - | - | ||
| 7 | 2020-12-12 | Defiance | 0 | 0 | Purdue Fort Wayne (222) | Cancelled | - | - |
| 8 | 2020-12-12 | Defiance | Purdue Fort Wayne (124) | Cancelled | - | - | ||
| 9 | 2020-12-13 | Defiance | 0 | 0 | Purdue Fort Wayne (222) | Cancelled | - | - |
| 10 | 2020-12-13 | Defiance | Purdue Fort Wayne (124) | Cancelled | - | - | ||
| 11 | 2020-12-19 | IUPUI (136) | Purdue Fort Wayne (144) | Cancelled | - | - | ||
| 12 | 2020-12-19 | Cleveland State (308) | 63 | 61 | Purdue Fort Wayne (222) | Final | L | -2 |
| 13 | 2020-12-20 | IUPUI (136) | Purdue Fort Wayne (144) | Cancelled | - | - | ||
| 14 | 2020-12-20 | Cleveland State (308) | 89 | 80 | Purdue Fort Wayne (222) | Final | L | -9 |
| 15 | 2020-12-26 | Robert Morris (148) | 102 | 88 | Purdue Fort Wayne (222) | Final | L | -14 |
| 16 | 2020-12-27 | Robert Morris (148) | 82 | 87 | Purdue Fort Wayne (222) | Final | W | 5 |
| 17 | 2021-01-01 | Purdue Fort Wayne (222) | 68 | 75 | Northern Kentucky (195) | Final | L | -7 |
| 18 | 2021-01-02 | Purdue Fort Wayne (222) | 68 | 70 | Northern Kentucky (195) | Final | L | -2 |
| 19 | 2021-01-08 | Illinois-Chicago (139) | 89 | 96 | Purdue Fort Wayne (222) | Final/OT | W | 7 |
| 20 | 2021-01-09 | Illinois-Chicago (139) | 55 | 88 | Purdue Fort Wayne (222) | Final | W | 33 |
| 21 | 2021-01-15 | Purdue Fort Wayne (222) | 81 | 72 | Milwaukee (261) | Final | W | 9 |
| 22 | 2021-01-16 | Purdue Fort Wayne (222) | 81 | 74 | Milwaukee (261) | Final | W | 7 |
| 23 | 2021-01-22 | Purdue Fort Wayne (222) | 59 | 77 | Green Bay (206) | Final | L | -18 |
| 24 | 2021-01-23 | Purdue Fort Wayne (222) | 72 | 87 | Green Bay (206) | Final | L | -15 |
| 25 | 2021-01-29 | Oakland (172) | 81 | 66 | Purdue Fort Wayne (222) | Final | L | -15 |
| 26 | 2021-01-30 | Oakland (172) | 82 | 75 | Purdue Fort Wayne (222) | Final | L | -7 |
| 27 | 2021-02-05 | Purdue Fort Wayne (222) | 72 | 82 | Detroit (212) | Final | L | -10 |
| 28 | 2021-02-06 | Purdue Fort Wayne (222) | 56 | 83 | Detroit (212) | Final | L | -27 |
| 29 | 2021-02-12 | Purdue Fort Wayne (222) | 70 | 84 | Youngstown State (231) | Final | L | -14 |
| 30 | 2021-02-13 | Purdue Fort Wayne (222) | 70 | 72 | Youngstown State (231) | Final | L | -2 |
| 31 | 2021-02-19 | Cleveland State (308) | 68 | 75 | Purdue Fort Wayne (222) | Final | W | 7 |
| 32 | 2021-02-20 | Cleveland State (308) | 67 | 55 | Purdue Fort Wayne (222) | Final | L | -12 |
| 33 | 2021-02-25 | Purdue Fort Wayne (222) | 89 | 84 | Green Bay (206) | Final/2OT | W | 5 |
| 34 | 2021-03-02 | Purdue Fort Wayne (222) | 104 | 108 | Cleveland State (308) | Final/3OT | L | -4 |