Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Coker | 0 | 0 | South Carolina (110) | Cancelled | - | - |
| 2 | 2020-11-28 | South Carolina (66) | Northwestern (163) | Cancelled | - | - | ||
| 3 | 2020-11-28 | South Carolina (110) | 62 | 78 | Liberty (93) | Final | L | -16 |
| 4 | 2020-11-29 | South Carolina (110) | 69 | 58 | Tulsa (55) | Final | W | 11 |
| 5 | 2020-11-29 | Tulsa (73) | 58 | 69 | South Carolina (66) | Final | W | 11 |
| 6 | 2020-12-05 | South Carolina (110) | 67 | 77 | Houston (5) | Final | L | -10 |
| 7 | 2020-12-10 | Wofford (221) | 0 | 0 | South Carolina (110) | Cancelled | - | - |
| 8 | 2020-12-10 | Wofford (84) | South Carolina (212) | Cancelled | - | - | ||
| 9 | 2020-12-14 | South Carolina (212) | George Washington (246) | Cancelled | - | - | ||
| 10 | 2020-12-19 | Clemson (36) | 0 | 0 | South Carolina (110) | Cancelled | - | - |
| 11 | 2020-12-23 | South Carolina State (355) | 0 | 0 | South Carolina (110) | Cancelled | - | - |
| 12 | 2020-12-23 | South Carolina State (354) | South Carolina (151) | Cancelled | - | - | ||
| 13 | 2020-12-29 | South Carolina (110) | 0 | 0 | Kentucky (26) | Postponed | - | - |
| 14 | 2021-01-02 | Florida A&M (297) | 71 | 78 | South Carolina (110) | Final | W | 7 |
| 15 | 2021-01-06 | Texas A&M (39) | 54 | 78 | South Carolina (110) | Final | W | 24 |
| 16 | 2021-01-09 | South Carolina (117) | 0 | 0 | Ole Miss (87) | Cancelled | - | - |
| 17 | 2021-01-12 | Tennessee (6) | 0 | 0 | South Carolina (74) | Cancelled | - | - |
| 18 | 2021-01-16 | South Carolina (110) | 80 | 85 | LSU (77) | Final | L | -5 |
| 19 | 2021-01-19 | South Carolina (110) | 70 | 81 | Missouri (51) | Final | L | -11 |
| 20 | 2021-01-23 | Auburn (37) | 109 | 86 | South Carolina (110) | Final | L | -23 |
| 21 | 2021-01-27 | Georgia (35) | 59 | 83 | South Carolina (110) | Final | W | 24 |
| 22 | 2021-01-30 | South Carolina (110) | 81 | 93 | Vanderbilt (17) | Final | L | -12 |
| 23 | 2021-02-03 | South Carolina (110) | 72 | 66 | Florida (6) | Final | W | 6 |
| 24 | 2021-02-06 | Mississippi State (100) | 75 | 59 | South Carolina (110) | Final | L | -16 |
| 25 | 2021-02-09 | Alabama (15) | 81 | 78 | South Carolina (110) | Final | L | -3 |
| 26 | 2021-02-13 | Ole Miss (79) | 81 | 74 | South Carolina (110) | Final | L | -7 |
| 27 | 2021-02-17 | South Carolina (110) | 73 | 93 | Tennessee (18) | Final | L | -20 |
| 28 | 2021-02-20 | Missouri (51) | 93 | 78 | South Carolina (110) | Final | L | -15 |
| 29 | 2021-02-24 | South Carolina (110) | 48 | 69 | Mississippi State (100) | Final | L | -21 |
| 30 | 2021-02-27 | South Carolina (110) | 91 | 70 | Georgia (35) | Final | W | 21 |
| 31 | 2021-03-02 | Arkansas (16) | 101 | 73 | South Carolina (110) | Final | L | -28 |
| 32 | 2021-03-06 | South Carolina (110) | 64 | 92 | Kentucky (26) | Final | L | -28 |
| 33 | 2021-03-11 | South Carolina (110) | 59 | 76 | Ole Miss (79) | Final | L | -17 |