Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Morehead State (233) | 45 | 81 | Kentucky (26) | Final | L | -36 |
| 2 | 2020-11-27 | Morehead State (233) | 64 | 82 | Richmond (166) | Final | L | -18 |
| 3 | 2020-11-29 | Arkansas State (147) | 61 | 69 | Morehead State (233) | Final | W | 8 |
| 4 | 2020-12-02 | Morehead State (233) | 44 | 77 | Ohio State (34) | Final | L | -33 |
| 5 | 2020-12-07 | Morehead State (233) | 68 | 71 | Eastern Kentucky (288) | Final | L | -3 |
| 6 | 2020-12-09 | Transylvania | 55 | 77 | Morehead State (233) | Final | W | 22 |
| 7 | 2020-12-10 | Transylvania | 55 | 81 | Morehead State (233) | Final | W | 26 |
| 8 | 2020-12-14 | Eastern Kentucky (288) | 62 | 75 | Morehead State (233) | Final | W | 13 |
| 9 | 2020-12-18 | SIU-Edwardsville (248) | 69 | 65 | Morehead State (233) | Final | L | -4 |
| 10 | 2020-12-21 | Morehead State (233) | 51 | 66 | Clemson (36) | Final | L | -15 |
| 11 | 2021-01-02 | Morehead State (233) | 61 | 56 | Murray State (116) | Final | W | 5 |
| 12 | 2021-01-07 | Tennessee Tech (310) | 54 | 57 | Morehead State (233) | Final | W | 3 |
| 13 | 2021-01-09 | Jacksonville State (227) | 55 | 56 | Morehead State (233) | Final | W | 1 |
| 14 | 2021-01-14 | Morehead State (233) | 87 | 61 | Eastern Illinois (314) | Final | W | 26 |
| 15 | 2021-01-16 | Morehead State (233) | 64 | 50 | Southeast Missouri State (226) | Final | W | 14 |
| 16 | 2021-01-21 | Southeast Missouri State (226) | 65 | 76 | Morehead State (233) | Final | W | 11 |
| 17 | 2021-01-23 | Tennessee-Martin (205) | 44 | 76 | Morehead State (233) | Final | W | 32 |
| 18 | 2021-01-28 | Morehead State (233) | 85 | 66 | Jacksonville State (227) | Final | W | 19 |
| 19 | 2021-01-30 | Morehead State (233) | 74 | 55 | Tennessee Tech (310) | Final | W | 19 |
| 20 | 2021-02-04 | Murray State (116) | 56 | 66 | Morehead State (233) | Final | W | 10 |
| 21 | 2021-02-06 | Austin Peay (138) | 74 | 75 | Morehead State (233) | Final/OT | W | 1 |
| 22 | 2021-02-11 | Morehead State (233) | 79 | 66 | Tennessee State (165) | Final | W | 13 |
| 23 | 2021-02-13 | Morehead State (233) | 58 | 73 | Belmont (68) | Final | L | -15 |
| 24 | 2021-02-19 | Morehead State (233) | 0 | 0 | Southeast Missouri State (226) | Cancelled | - | - |
| 25 | 2021-02-20 | Morehead State (233) | 79 | 69 | Tennessee-Martin (205) | Final | W | 10 |
| 26 | 2021-02-22 | Morehead State (233) | 56 | 48 | SIU-Edwardsville (248) | Final | W | 8 |
| 27 | 2021-02-25 | Tennessee State (165) | 60 | 74 | Morehead State (233) | Final | W | 14 |
| 28 | 2021-02-27 | Belmont (68) | 82 | 89 | Morehead State (233) | Final/OT | W | 7 |
| 29 | 2021-03-03 | Southeast Missouri State (226) | 54 | 61 | Morehead State (233) | Final | W | 7 |
| 30 | 2021-03-05 | Eastern Kentucky (288) | 64 | 67 | Morehead State (233) | Final | W | 3 |
| 31 | 2021-03-06 | Morehead State (233) | 86 | 71 | Belmont (68) | Final | W | 15 |
| 32 | 2021-03-19 | Morehead State (103) | 67 | 84 | West Virginia (17) | Final | L | -17 |