Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Mississippi State (100) | 42 | 53 | Clemson (36) | Final | L | -11 |
| 2 | 2020-11-25 | Clemson (74) | 53 | 42 | Mississippi State (53) | Final | L | -11 |
| 3 | 2020-11-26 | Liberty (93) | 84 | 73 | Mississippi State (100) | Final | L | -11 |
| 4 | 2020-11-30 | Texas State (199) | 51 | 68 | Mississippi State (100) | Final | W | 17 |
| 5 | 2020-12-04 | North Texas (125) | 63 | 69 | Mississippi State (100) | Final | W | 6 |
| 6 | 2020-12-08 | Jackson State (329) | 59 | 82 | Mississippi State (100) | Final | W | 23 |
| 7 | 2020-12-12 | Dayton (127) | 85 | 82 | Mississippi State (112) | Final (2OT) | L | -3 |
| 8 | 2020-12-12 | Mississippi State (100) | 82 | 85 | Dayton (66) | Final/2OT | L | -3 |
| 9 | 2020-12-16 | Central Arkansas (143) | 65 | 81 | Mississippi State (100) | Final | W | 16 |
| 10 | 2020-12-21 | Mississippi Valley State (365) | 48 | 87 | Mississippi State (100) | Final | W | 39 |
| 11 | 2020-12-30 | Mississippi State (100) | 83 | 73 | Georgia (35) | Final | W | 10 |
| 12 | 2021-01-02 | Kentucky (26) | 78 | 73 | Mississippi State (100) | Final/2OT | L | -5 |
| 13 | 2021-01-05 | Missouri (51) | 63 | 78 | Mississippi State (100) | Final | W | 15 |
| 14 | 2021-01-09 | Mississippi State (100) | 84 | 81 | Vanderbilt (17) | Final | W | 3 |
| 15 | 2021-01-13 | Texas A&M (39) | 56 | 55 | Mississippi State (100) | Final | L | -1 |
| 16 | 2021-01-16 | Florida (6) | 69 | 72 | Mississippi State (100) | Final | W | 3 |
| 17 | 2021-01-19 | Ole Miss (79) | 64 | 46 | Mississippi State (100) | Final | L | -18 |
| 18 | 2021-01-23 | Mississippi State (100) | 73 | 81 | Alabama (15) | Final | L | -8 |
| 19 | 2021-01-26 | Mississippi State (100) | 53 | 56 | Tennessee (18) | Final | L | -3 |
| 20 | 2021-01-30 | Iowa State (7) | 56 | 95 | Mississippi State (100) | Final | W | 39 |
| 21 | 2021-02-02 | Mississippi State (100) | 45 | 61 | Arkansas (16) | Final | L | -16 |
| 22 | 2021-02-06 | Mississippi State (100) | 75 | 59 | South Carolina (110) | Final | W | 16 |
| 23 | 2021-02-10 | LSU (77) | 94 | 80 | Mississippi State (100) | Final | L | -14 |
| 24 | 2021-02-13 | Vanderbilt (17) | 72 | 51 | Mississippi State (100) | Final | L | -21 |
| 25 | 2021-02-18 | Mississippi State (100) | 0 | 0 | Auburn (37) | Postponed | - | - |
| 26 | 2021-02-20 | Mississippi State (100) | 66 | 56 | Ole Miss (79) | Final | W | 10 |
| 27 | 2021-02-24 | South Carolina (110) | 48 | 69 | Mississippi State (100) | Final | W | 21 |
| 28 | 2021-02-27 | Alabama (15) | 64 | 59 | Mississippi State (100) | Final | L | -5 |
| 29 | 2021-03-03 | Mississippi State (100) | 63 | 57 | Texas A&M (39) | Final | W | 6 |
| 30 | 2021-03-06 | Mississippi State (100) | 71 | 78 | Auburn (37) | Final | L | -7 |
| 31 | 2021-03-11 | Mississippi State (100) | 74 | 73 | Kentucky (26) | Final | W | 1 |
| 32 | 2021-03-12 | Mississippi State (100) | 48 | 85 | Alabama (15) | Final | L | -37 |
| 33 | 2021-03-20 | Mississippi State (82) | 74 | 68 | Saint Louis (53) | Final | W | 6 |
| 34 | 2021-03-25 | Mississippi State (82) | 68 | 67 | Richmond (75) | Final | W | 1 |
| 35 | 2021-03-27 | Louisiana Tech (70) | 62 | 84 | Mississippi State (82) | Final | W | 22 |
| 36 | 2021-03-28 | Mississippi State (82) | 64 | 77 | Memphis (48) | Final | L | -13 |