Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-24 | Prairie View A&M (285) | 0 | 0 | Northwestern (75) | Cancelled | - | - |
| 2 | 2020-11-28 | South Carolina (66) | Northwestern (163) | Cancelled | - | - | ||
| 3 | 2020-12-02 | Arkansas-Pine Bluff (303) | 49 | 92 | Northwestern (75) | Final | W | 43 |
| 4 | 2020-12-05 | Chicago State (351) | 66 | 111 | Northwestern (75) | Final | W | 45 |
| 5 | 2020-12-09 | Pittsburgh (108) | 71 | 70 | Northwestern (75) | Final | L | -1 |
| 6 | 2020-12-13 | SIU-Edwardsville (248) | 0 | 0 | Northwestern (75) | Cancelled | - | - |
| 7 | 2020-12-15 | Quincy | 48 | 100 | Northwestern (75) | Final | W | 52 |
| 8 | 2020-12-20 | Michigan State (10) | 65 | 79 | Northwestern (75) | Final | W | 14 |
| 9 | 2020-12-23 | Northwestern (75) | 74 | 67 | Indiana (46) | Final | W | 7 |
| 10 | 2020-12-26 | Ohio State (34) | 70 | 71 | Northwestern (75) | Final | W | 1 |
| 11 | 2020-12-29 | Northwestern (75) | 72 | 87 | Iowa (28) | Final | L | -15 |
| 12 | 2021-01-03 | Northwestern (75) | 66 | 85 | Michigan (1) | Final | L | -19 |
| 13 | 2021-01-07 | Illinois (9) | 81 | 56 | Northwestern (75) | Final | L | -25 |
| 14 | 2021-01-13 | Northwestern (75) | 71 | 81 | Ohio State (34) | Final | L | -10 |
| 15 | 2021-01-17 | Iowa (28) | 96 | 73 | Northwestern (75) | Final | L | -23 |
| 16 | 2021-01-20 | Northwestern (75) | 52 | 68 | Wisconsin (24) | Final | L | -16 |
| 17 | 2021-01-23 | Northwestern (75) | 78 | 81 | Penn State (129) | Final | L | -3 |
| 18 | 2021-01-31 | Rutgers (112) | 64 | 56 | Northwestern (75) | Final | L | -8 |
| 19 | 2021-02-03 | Michigan (1) | 0 | 0 | Northwestern (75) | Cancelled | - | - |
| 20 | 2021-02-06 | Northwestern (75) | 70 | 75 | Purdue (8) | Final | L | -5 |
| 21 | 2021-02-10 | Indiana (46) | 79 | 76 | Northwestern (75) | Final/2OT | L | -3 |
| 22 | 2021-02-13 | Northwestern (75) | 50 | 64 | Rutgers (112) | Final | L | -14 |
| 23 | 2021-02-16 | Northwestern (75) | 66 | 73 | Illinois (9) | Final | L | -7 |
| 24 | 2021-02-21 | Wisconsin (24) | 68 | 51 | Northwestern (75) | Final | L | -17 |
| 25 | 2021-02-25 | Northwestern (75) | 67 | 59 | Minnesota (87) | Final | W | 8 |
| 26 | 2021-03-03 | Maryland (114) | 55 | 60 | Northwestern (75) | Final | W | 5 |
| 27 | 2021-03-07 | Nebraska (13) | 78 | 79 | Northwestern (75) | Final | W | 1 |
| 28 | 2021-03-10 | Minnesota (64) | 51 | 46 | Northwestern (89) | Final | L | -5 |