Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Bowling Green (168) | 82 | 96 | Michigan (1) | Final | W | 14 |
| 2 | 2020-11-29 | Oakland (172) | 71 | 81 | Michigan (1) | Final/OT | W | 10 |
| 3 | 2020-12-02 | Ball State (298) | 65 | 84 | Michigan (1) | Final | W | 19 |
| 4 | 2020-12-06 | Central Florida (43) | 58 | 80 | Michigan (1) | Final | W | 22 |
| 5 | 2020-12-09 | North Carolina State (31) | 0 | 0 | Michigan (13) | Cancelled | - | - |
| 6 | 2020-12-09 | Toledo (135) | 71 | 91 | Michigan (1) | Final | W | 20 |
| 7 | 2020-12-13 | Penn State (129) | 58 | 62 | Michigan (1) | Final | W | 4 |
| 8 | 2020-12-25 | Michigan (3) | 80 | 69 | Nebraska (126) | Final | W | 11 |
| 9 | 2020-12-31 | Michigan (1) | 84 | 73 | Maryland (114) | Final | W | 11 |
| 10 | 2021-01-03 | Northwestern (75) | 66 | 85 | Michigan (1) | Final | W | 19 |
| 11 | 2021-01-06 | Minnesota (87) | 57 | 82 | Michigan (1) | Final | W | 25 |
| 12 | 2021-01-09 | Michigan (1) | 0 | 0 | Penn State (129) | Cancelled | - | - |
| 13 | 2021-01-12 | Wisconsin (24) | 54 | 77 | Michigan (1) | Final | W | 23 |
| 14 | 2021-01-16 | Michigan (1) | 57 | 75 | Minnesota (87) | Final | L | -18 |
| 15 | 2021-01-19 | Maryland (114) | 63 | 87 | Michigan (1) | Final | W | 24 |
| 16 | 2021-01-22 | Michigan (1) | 70 | 53 | Purdue (8) | Final | W | 17 |
| 17 | 2021-01-27 | Michigan (3) | 0 | 0 | Penn State (57) | Cancelled | - | - |
| 18 | 2021-01-30 | Indiana (46) | 0 | 0 | Michigan (1) | Cancelled | - | - |
| 19 | 2021-02-03 | Michigan (1) | 0 | 0 | Northwestern (75) | Cancelled | - | - |
| 20 | 2021-02-06 | Michigan State (81) | 0 | 0 | Michigan (4) | Cancelled | - | - |
| 21 | 2021-02-11 | Illinois (9) | 0 | 0 | Michigan (1) | Postponed | - | - |
| 22 | 2021-02-14 | Michigan (1) | 67 | 59 | Wisconsin (24) | Final | W | 8 |
| 23 | 2021-02-18 | Rutgers (112) | 64 | 71 | Michigan (1) | Final | W | 7 |
| 24 | 2021-02-21 | Michigan (1) | 92 | 87 | Ohio State (34) | Final | W | 5 |
| 25 | 2021-02-25 | Iowa (28) | 57 | 79 | Michigan (1) | Final | W | 22 |
| 26 | 2021-02-27 | Michigan (1) | 73 | 57 | Indiana (46) | Final | W | 16 |
| 27 | 2021-03-02 | Illinois (9) | 76 | 53 | Michigan (1) | Final | L | -23 |
| 28 | 2021-03-04 | Michigan State (10) | 50 | 69 | Michigan (1) | Final | W | 19 |
| 29 | 2021-03-07 | Michigan (1) | 64 | 70 | Michigan State (10) | Final | L | -6 |
| 30 | 2021-03-12 | Maryland (114) | 66 | 79 | Michigan (1) | Final | W | 13 |
| 31 | 2021-03-13 | Ohio State (9) | 68 | 67 | Michigan (3) | Final | L | -1 |
| 32 | 2021-03-20 | Texas Southern (171) | 66 | 82 | Michigan (4) | Final | W | 16 |
| 33 | 2021-03-22 | LSU (26) | 78 | 86 | Michigan (4) | Final | W | 8 |
| 34 | 2021-03-28 | Florida State (20) | 58 | 76 | Michigan (4) | Final | W | 18 |
| 35 | 2021-03-30 | UCLA (42) | 51 | 49 | Michigan (4) | Final | L | -2 |