NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Southern Illinois (195) | 49 | 59 | Tennessee (11) | Final | L | -10 |
| 2 | 2021-11-14 | Southern Illinois (195) | 46 | 67 | UMKC (237) | Final | L | -21 |
| 3 | 2021-11-24 | IUPUI (125) | 0 | 0 | Southern Illinois (244) | Cancelled | - | - |
| 4 | 2021-11-30 | Southern Illinois (206) | 78 | 61 | Southeast Missouri State (298) | Final | W | 17 |
| 5 | 2021-12-03 | Eastern Illinois (183) | 66 | 74 | Southern Illinois (206) | Final | W | 8 |
| 6 | 2021-12-04 | Southern Illinois (291) | 80 | 85 | Western Illinois (91) | Final | L | -5 |
| 7 | 2021-12-12 | Quincy | 45 | 70 | Southern Illinois (153) | Final | W | 25 |
| 8 | 2021-12-15 | Southern Illinois (142) | 69 | 54 | Tennessee-Martin (200) | Final | W | 15 |
| 9 | 2021-12-17 | Southern Illinois (142) | 61 | 62 | Middle Tennessee (68) | Final | L | -1 |
| 10 | 2021-12-19 | Illinois (29) | 51 | 66 | Southern Illinois (291) | Final | W | 15 |
| 11 | 2021-12-23 | Southern Illinois (144) | 37 | 70 | Indiana (19) | Final | L | -33 |
| 12 | 2021-12-31 | Valparaiso (360) | 52 | 62 | Southern Illinois (291) | Final | W | 10 |
| 13 | 2022-01-02 | Loyola-Chicago (175) | 50 | 63 | Southern Illinois (291) | Final | W | 13 |
| 14 | 2022-01-07 | Southern Illinois (133) | 0 | 0 | Missouri State (22) | Postponed | - | - |
| 15 | 2022-01-13 | Southern Illinois (291) | 60 | 49 | Drake (236) | Final | W | 11 |
| 16 | 2022-01-15 | Southern Illinois (124) | 57 | 66 | Northern Iowa (95) | Final | L | -9 |
| 17 | 2022-01-20 | Illinois State (192) | 47 | 56 | Southern Illinois (128) | Final | W | 9 |
| 18 | 2022-01-22 | Bradley (306) | 41 | 53 | Southern Illinois (128) | Final | W | 12 |
| 19 | 2022-01-27 | Southern Illinois (291) | 0 | 0 | Indiana State (285) | Postponed | - | - |
| 20 | 2022-01-29 | Southern Illinois (125) | 75 | 62 | Evansville (288) | Final | W | 13 |
| 21 | 2022-02-04 | Missouri State (44) | 49 | 65 | Southern Illinois (115) | Final | W | 16 |
| 22 | 2022-02-06 | Southern Illinois (115) | 52 | 53 | Missouri State (44) | Final | L | -1 |
| 23 | 2022-02-09 | Southern Illinois (291) | 79 | 55 | Indiana State (285) | Final | W | 24 |
| 24 | 2022-02-11 | Northern Iowa (69) | 60 | 64 | Southern Illinois (105) | Final | W | 4 |
| 25 | 2022-02-13 | Drake (115) | 65 | 73 | Southern Illinois (105) | Final | W | 8 |
| 26 | 2022-02-18 | Southern Illinois (86) | 74 | 46 | Bradley (304) | Final | W | 28 |
| 27 | 2022-02-20 | Southern Illinois (86) | 65 | 49 | Illinois State (139) | Final | W | 16 |
| 28 | 2022-02-24 | Indiana State (246) | 46 | 63 | Southern Illinois (83) | Final | W | 17 |
| 29 | 2022-02-26 | Evansville (297) | 66 | 80 | Southern Illinois (83) | Final | W | 14 |
| 30 | 2022-03-03 | Southern Illinois (82) | 51 | 28 | Loyola-Chicago (149) | Final | W | 23 |
| 31 | 2022-03-05 | Southern Illinois (82) | 54 | 67 | Valparaiso (263) | Final | L | -13 |
| 32 | 2022-03-11 | Indiana State (245) | 61 | 77 | Southern Illinois (89) | Final | W | 16 |
| 33 | 2022-03-12 | Illinois State (167) | 50 | 42 | Southern Illinois (89) | Final | L | -8 |
| 34 | 2022-03-16 | Southern Illinois (92) | 60 | 82 | Purdue (84) | Final | L | -22 |