NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | St. Louis Pharmacy | 45 | 68 | Southeast Missouri State (148) | Final | W | 23 |
| 2 | 2021-11-15 | Southeast Missouri State (148) | 59 | 83 | Stephen F. Austin (27) | Final | L | -24 |
| 3 | 2021-11-17 | Southeast Missouri State (241) | 47 | 88 | Texas (12) | Final | L | -41 |
| 4 | 2021-11-22 | Arkansas State (142) | 73 | 65 | Southeast Missouri State (241) | Final | L | -8 |
| 5 | 2021-11-26 | Southeast Missouri State (243) | 82 | 76 | Mississippi Valley State (342) | Final | W | 6 |
| 6 | 2021-11-27 | Arkansas-Pine Bluff (313) | 81 | 63 | Southeast Missouri State (298) | Final | L | -18 |
| 7 | 2021-11-30 | Southern Illinois (206) | 78 | 61 | Southeast Missouri State (298) | Final | L | -17 |
| 8 | 2021-12-03 | Saint Louis (226) | 83 | 54 | Southeast Missouri State (298) | Final | L | -29 |
| 9 | 2021-12-05 | Harris Stowe | 57 | 95 | Southeast Missouri State (298) | Final | W | 38 |
| 10 | 2021-12-09 | Purdue Fort Wayne (280) | 51 | 68 | Southeast Missouri State (307) | Final | W | 17 |
| 11 | 2021-12-19 | Southeast Missouri State (243) | 58 | 65 | Xavier (190) | Final | L | -7 |
| 12 | 2021-12-30 | Southeast Missouri State (302) | 58 | 82 | Murray State (153) | Final | L | -24 |
| 13 | 2022-01-01 | Austin Peay (182) | 72 | 62 | Southeast Missouri State (302) | Final | L | -10 |
| 14 | 2022-01-06 | Southeast Missouri State (314) | 65 | 85 | Belmont (106) | Final | L | -20 |
| 15 | 2022-01-08 | Southeast Missouri State (243) | 64 | 83 | Tennessee State (322) | Final | L | -19 |
| 16 | 2022-01-13 | Tennessee Tech (222) | 75 | 58 | Southeast Missouri State (243) | Final | L | -17 |
| 17 | 2022-01-15 | Southeast Missouri State (321) | 66 | 73 | SIU-Edwardsville (235) | Final | L | -7 |
| 18 | 2022-01-20 | Tennessee State (196) | 68 | 53 | Southeast Missouri State (325) | Final | L | -15 |
| 19 | 2022-01-22 | Southeast Missouri State (325) | 44 | 68 | Eastern Illinois (253) | Final | L | -24 |
| 20 | 2022-01-27 | Morehead State (183) | 53 | 60 | Southeast Missouri State (243) | Final | W | 7 |
| 21 | 2022-01-29 | SIU-Edwardsville (252) | 69 | 61 | Southeast Missouri State (331) | Final | L | -8 |
| 22 | 2022-02-03 | Southeast Missouri State (328) | 66 | 70 | Tennessee-Martin (243) | Final | L | -4 |
| 23 | 2022-02-05 | Eastern Illinois (329) | 72 | 53 | Southeast Missouri State (243) | Final | L | -19 |
| 24 | 2022-02-10 | Southeast Missouri State (243) | 38 | 79 | Austin Peay (177) | Final | L | -41 |
| 25 | 2022-02-12 | Belmont (82) | 70 | 67 | Southeast Missouri State (332) | Final | L | -3 |
| 26 | 2022-02-17 | Southeast Missouri State (332) | 55 | 65 | Tennessee Tech (137) | Final | L | -10 |
| 27 | 2022-02-19 | Southeast Missouri State (332) | 70 | 62 | Morehead State (353) | Final | W | 8 |
| 28 | 2022-02-24 | Tennessee-Martin (211) | 70 | 49 | Southeast Missouri State (329) | Final | L | -21 |
| 29 | 2022-02-26 | Murray State (125) | 86 | 54 | Southeast Missouri State (329) | Final | L | -32 |