NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Lindenwood | 30 | 86 | Eastern Illinois (216) | Final | W | 56 |
| 2 | 2021-11-17 | Eastern Illinois (143) | 64 | 55 | Indiana State (246) | Final | W | 9 |
| 3 | 2021-11-20 | Evansville (102) | 74 | 85 | Eastern Illinois (143) | Final/2OT | W | 11 |
| 4 | 2021-11-22 | Oakland City | 60 | 79 | Eastern Illinois (143) | Final | W | 19 |
| 5 | 2021-11-26 | Eastern Illinois (329) | 50 | 71 | Hawaii (134) | Final | L | -21 |
| 6 | 2021-11-27 | Eastern Illinois (74) | 53 | 74 | Gonzaga (91) | Final | L | -21 |
| 7 | 2021-11-28 | Utah (19) | 93 | 77 | Eastern Illinois (74) | Final | L | -16 |
| 8 | 2021-12-03 | Eastern Illinois (183) | 66 | 74 | Southern Illinois (206) | Final | L | -8 |
| 9 | 2021-12-04 | Eastern Illinois (329) | 87 | 81 | Northern Illinois (310) | Final | W | 6 |
| 10 | 2021-12-08 | Eastern Illinois (190) | 48 | 58 | Loyola-Chicago (194) | Final | L | -10 |
| 11 | 2021-12-20 | Lipscomb (299) | 54 | 47 | Eastern Illinois (195) | Final | L | -7 |
| 12 | 2021-12-23 | Eastern Illinois (224) | 0 | 0 | Wisconsin (291) | Cancelled | - | - |
| 13 | 2021-12-29 | Eastern Illinois (231) | 91 | 64 | Morehead State (349) | Final | W | 27 |
| 14 | 2022-01-01 | Belmont (120) | 71 | 57 | Eastern Illinois (231) | Final | L | -14 |
| 15 | 2022-01-13 | SIU-Edwardsville (242) | 0 | 0 | Eastern Illinois (329) | Postponed | - | - |
| 16 | 2022-01-15 | Eastern Illinois (233) | 72 | 75 | Austin Peay (206) | Final | L | -3 |
| 17 | 2022-01-17 | Murray State (158) | 80 | 71 | Eastern Illinois (233) | Final | L | -9 |
| 18 | 2022-01-20 | Eastern Illinois (253) | 71 | 64 | Murray State (142) | Final/OT | W | 7 |
| 19 | 2022-01-22 | Southeast Missouri State (325) | 44 | 68 | Eastern Illinois (253) | Final | W | 24 |
| 20 | 2022-01-24 | Eastern Illinois (253) | 60 | 65 | Tennessee Tech (182) | Final | L | -5 |
| 21 | 2022-01-27 | Eastern Illinois (329) | 81 | 77 | Tennessee-Martin (249) | Final | W | 4 |
| 22 | 2022-01-29 | Tennessee State (204) | 70 | 78 | Eastern Illinois (224) | Final/OT | W | 8 |
| 23 | 2022-01-31 | SIU-Edwardsville (242) | 65 | 89 | Eastern Illinois (329) | Final | W | 24 |
| 24 | 2022-02-03 | Eastern Illinois (196) | 0 | 0 | SIU-Edwardsville (253) | Postponed | - | - |
| 25 | 2022-02-05 | Eastern Illinois (329) | 72 | 53 | Southeast Missouri State (243) | Final | W | 19 |
| 26 | 2022-02-07 | Eastern Illinois (329) | 70 | 68 | SIU-Edwardsville (242) | Final | W | 2 |
| 27 | 2022-02-10 | Tennessee Tech (222) | 65 | 56 | Eastern Illinois (329) | Final | L | -9 |
| 28 | 2022-02-12 | Tennessee-Martin (233) | 58 | 45 | Eastern Illinois (193) | Final | L | -13 |
| 29 | 2022-02-17 | Eastern Illinois (202) | 46 | 77 | Belmont (84) | Final | L | -31 |
| 30 | 2022-02-19 | Eastern Illinois (202) | 72 | 61 | Tennessee State (259) | Final | W | 11 |
| 31 | 2022-02-24 | Morehead State (354) | 56 | 68 | Eastern Illinois (206) | Final | W | 12 |
| 32 | 2022-02-26 | Austin Peay (173) | 56 | 68 | Eastern Illinois (206) | Final | W | 12 |
| 33 | 2022-03-02 | Tennessee State (274) | 72 | 61 | Eastern Illinois (197) | Final | L | -11 |