NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-11 | Western Illinois (91) | 50 | 76 | Notre Dame (20) | Final | L | -26 |
| 2 | 2021-11-13 | Western Illinois (258) | 73 | 46 | Butler (277) | Final | W | 27 |
| 3 | 2021-11-17 | Chicago State (347) | 50 | 77 | Western Illinois (146) | Final | W | 27 |
| 4 | 2021-11-20 | Bellarmine (253) | 82 | 105 | Western Illinois (146) | Final | W | 23 |
| 5 | 2021-11-23 | Missouri Baptist | 43 | 103 | Western Illinois (91) | Final | W | 60 |
| 6 | 2021-11-27 | Western Illinois (103) | 58 | 54 | Tarleton State (252) | Final | W | 4 |
| 7 | 2021-11-29 | Western Illinois (103) | 59 | 63 | Incarnate Word (326) | Final | L | -4 |
| 8 | 2021-12-03 | Northern Illinois (119) | 83 | 92 | Western Illinois (141) | Final/OT | W | 9 |
| 9 | 2021-12-04 | Southern Illinois (291) | 80 | 85 | Western Illinois (91) | Final | W | 5 |
| 10 | 2021-12-07 | Western Illinois (114) | 96 | 93 | SIU-Edwardsville (169) | Final | W | 3 |
| 11 | 2021-12-11 | Greenville | 56 | 105 | Western Illinois (114) | Final | W | 49 |
| 12 | 2021-12-20 | Denver (277) | 66 | 72 | Western Illinois (110) | Final | W | 6 |
| 13 | 2021-12-22 | Nebraska-Omaha (184) | 70 | 77 | Western Illinois (106) | Final | W | 7 |
| 14 | 2022-01-01 | St. Thomas (317) | 66 | 64 | Western Illinois (105) | Final/2OT | L | -2 |
| 15 | 2022-01-06 | Western Illinois (128) | 0 | 0 | UMKC (83) | Postponed | - | - |
| 16 | 2022-01-08 | Western Illinois (91) | 0 | 0 | Oral Roberts (203) | Postponed | - | - |
| 17 | 2022-01-13 | North Dakota (332) | 76 | 65 | Western Illinois (91) | Final | L | -11 |
| 18 | 2022-01-15 | North Dakota State (230) | 63 | 55 | Western Illinois (127) | Final | L | -8 |
| 19 | 2022-01-20 | Western Illinois (177) | 53 | 70 | South Dakota (37) | Final | L | -17 |
| 20 | 2022-01-22 | Western Illinois (177) | 50 | 114 | South Dakota State (81) | Final | L | -64 |
| 21 | 2022-01-29 | Western Illinois (194) | 82 | 67 | St. Thomas (296) | Final | W | 15 |
| 22 | 2022-01-31 | Western Illinois (91) | 66 | 74 | UMKC (309) | Final | L | -8 |
| 23 | 2022-02-03 | Oral Roberts (202) | 71 | 55 | Western Illinois (195) | Final | L | -16 |
| 24 | 2022-02-05 | UMKC (309) | 87 | 85 | Western Illinois (91) | Final/OT | L | -2 |
| 25 | 2022-02-10 | Western Illinois (91) | 61 | 59 | North Dakota State (59) | Final | W | 2 |
| 26 | 2022-02-12 | Western Illinois (209) | 85 | 73 | North Dakota (186) | Final | W | 12 |
| 27 | 2022-02-14 | Western Illinois (209) | 74 | 93 | Oral Roberts (191) | Final | L | -19 |
| 28 | 2022-02-17 | South Dakota State (58) | 84 | 54 | Western Illinois (204) | Final | L | -30 |
| 29 | 2022-02-19 | South Dakota (45) | 0 | 0 | Western Illinois (204) | Postponed | - | - |
| 30 | 2022-02-24 | Western Illinois (210) | 0 | 0 | Nebraska-Omaha (270) | Postponed | - | - |
| 31 | 2022-02-26 | Western Illinois (210) | 55 | 77 | Denver (288) | Final | L | -22 |
| 32 | 2022-02-28 | South Dakota (45) | 75 | 48 | Western Illinois (210) | Final | L | -27 |
| 33 | 2022-03-05 | Western Illinois (223) | 49 | 75 | South Dakota (40) | Final | L | -26 |