NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Purdue (140) | 79 | 69 | Western Kentucky (212) | Final | L | -10 |
| 2 | 2021-11-12 | Western Kentucky (282) | 86 | 76 | North Carolina A&T (264) | Final | W | 10 |
| 3 | 2021-11-14 | Western Kentucky (212) | 44 | 76 | Kansas State (117) | Final | L | -32 |
| 4 | 2021-11-15 | Tennessee-Martin (54) | 63 | 47 | Western Kentucky (212) | Final | L | -16 |
| 5 | 2021-11-21 | Kentucky State | 59 | 96 | Western Kentucky (262) | Final | W | 37 |
| 6 | 2021-11-24 | Indiana State (264) | 65 | 83 | Western Kentucky (263) | Final | W | 18 |
| 7 | 2021-11-28 | Tennessee State (241) | 65 | 77 | Western Kentucky (263) | Final | W | 12 |
| 8 | 2021-12-02 | Western Kentucky (181) | 64 | 55 | Bellarmine (314) | Final | W | 9 |
| 9 | 2021-12-05 | Tennessee Tech (247) | 76 | 72 | Western Kentucky (181) | Final | L | -4 |
| 10 | 2021-12-15 | Western Kentucky (179) | 60 | 58 | Miami (OH) (211) | Final | W | 2 |
| 11 | 2021-12-17 | Western Kentucky (179) | 92 | 88 | Fairleigh Dickinson (228) | Final/2OT | W | 4 |
| 12 | 2021-12-22 | Western Kentucky (164) | 0 | 0 | Belmont (122) | Cancelled | - | - |
| 13 | 2021-12-30 | Southern Miss (189) | 88 | 98 | Western Kentucky (169) | Final | W | 10 |
| 14 | 2022-01-01 | Louisiana Tech (139) | 50 | 64 | Western Kentucky (169) | Final | W | 14 |
| 15 | 2022-01-08 | Western Kentucky (282) | 63 | 51 | Florida International (139) | Final | W | 12 |
| 16 | 2022-01-13 | Western Kentucky (282) | 78 | 61 | Rice (58) | Final | W | 17 |
| 17 | 2022-01-15 | Western Kentucky (126) | 61 | 54 | North Texas (119) | Final | W | 7 |
| 18 | 2022-01-20 | Florida Atlantic (296) | 49 | 73 | Western Kentucky (116) | Final | W | 24 |
| 19 | 2022-01-22 | Florida International (206) | 66 | 87 | Western Kentucky (116) | Final | W | 21 |
| 20 | 2022-01-27 | Western Kentucky (282) | 70 | 86 | UAB (217) | Final | L | -16 |
| 21 | 2022-01-29 | Western Kentucky (100) | 64 | 71 | Middle Tennessee (75) | Final | L | -7 |
| 22 | 2022-02-03 | Charlotte (109) | 79 | 74 | Western Kentucky (116) | Final/OT | L | -5 |
| 23 | 2022-02-05 | Old Dominion (126) | 57 | 71 | Western Kentucky (282) | Final | W | 14 |
| 24 | 2022-02-10 | Western Kentucky (282) | 72 | 69 | Florida Atlantic (205) | Final/OT | W | 3 |
| 25 | 2022-02-13 | UTSA (284) | 70 | 81 | Western Kentucky (112) | Final | W | 11 |
| 26 | 2022-02-17 | Western Kentucky (115) | 43 | 89 | Charlotte (104) | Final | L | -46 |
| 27 | 2022-02-19 | Western Kentucky (115) | 55 | 75 | Old Dominion (79) | Final | L | -20 |
| 28 | 2022-02-26 | Middle Tennessee (66) | 93 | 97 | Western Kentucky (127) | Final/OT | W | 4 |
| 29 | 2022-03-02 | Marshall (182) | 80 | 62 | Western Kentucky (120) | Final | L | -18 |
| 30 | 2022-03-05 | Western Kentucky (120) | 51 | 58 | Marshall (182) | Final | L | -7 |
| 31 | 2022-03-09 | UAB (205) | 74 | 62 | Western Kentucky (143) | Final | L | -12 |