NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Ohio (87) | 69 | 105 | Notre Dame (60) | Final | W | 36 |
| 2 | 2021-11-11 | Western Illinois (91) | 50 | 76 | Notre Dame (20) | Final | W | 26 |
| 3 | 2021-11-14 | Notre Dame (60) | 82 | 56 | Syracuse (39) | Final | W | 26 |
| 4 | 2021-11-18 | Fordham (261) | 56 | 71 | Notre Dame (20) | Final | W | 15 |
| 5 | 2021-11-21 | Bryant (322) | 35 | 94 | Notre Dame (5) | Final | W | 59 |
| 6 | 2021-11-26 | Notre Dame (20) | 67 | 71 | Georgia (30) | Final/OT | L | -4 |
| 7 | 2021-11-27 | Notre Dame (4) | 64 | 62 | Oregon State (31) | Final | W | 2 |
| 8 | 2021-12-02 | Notre Dame (13) | 76 | 71 | Michigan State (103) | Final | W | 5 |
| 9 | 2021-12-05 | Notre Dame (13) | 54 | 73 | Connecticut (12) | Final | L | -19 |
| 10 | 2021-12-08 | Notre Dame (19) | 73 | 56 | Valparaiso (347) | Final | W | 17 |
| 11 | 2021-12-12 | Purdue Fort Wayne (280) | 41 | 78 | Notre Dame (19) | Final | W | 37 |
| 12 | 2021-12-19 | Pittsburgh (279) | 59 | 85 | Notre Dame (20) | Final | W | 26 |
| 13 | 2021-12-22 | Notre Dame (16) | 91 | 86 | DePaul (26) | Final | W | 5 |
| 14 | 2021-12-30 | Notre Dame (14) | 0 | 0 | Virginia (194) | Postponed | - | - |
| 15 | 2022-01-02 | Notre Dame (20) | 70 | 72 | Duke (8) | Final | L | -2 |
| 16 | 2022-01-13 | Notre Dame (20) | 74 | 64 | Wake Forest (154) | Final | W | 10 |
| 17 | 2022-01-16 | North Carolina (14) | 65 | 70 | Notre Dame (20) | Final | W | 5 |
| 18 | 2022-01-20 | Notre Dame (16) | 71 | 73 | Boston College (47) | Final | L | -2 |
| 19 | 2022-01-23 | Notre Dame (20) | 77 | 63 | Pittsburgh (279) | Final | W | 14 |
| 20 | 2022-01-25 | Notre Dame (21) | 0 | 0 | Virginia (199) | Postponed | - | - |
| 21 | 2022-01-27 | Syracuse (34) | 62 | 83 | Notre Dame (20) | Final | W | 21 |
| 22 | 2022-01-30 | Boston College (36) | 61 | 74 | Notre Dame (21) | Final | W | 13 |
| 23 | 2022-02-01 | North Carolina State (2) | 66 | 69 | Notre Dame (20) | Final | W | 3 |
| 24 | 2022-02-03 | Virginia Tech (31) | 55 | 68 | Notre Dame (20) | Final | W | 13 |
| 25 | 2022-02-06 | Notre Dame (20) | 65 | 70 | Florida State (84) | Final | L | -5 |
| 26 | 2022-02-10 | Miami (64) | 53 | 69 | Notre Dame (20) | Final | W | 16 |
| 27 | 2022-02-13 | Notre Dame (18) | 47 | 73 | Louisville (4) | Final | L | -26 |
| 28 | 2022-02-17 | Notre Dame (18) | 72 | 66 | Georgia Tech (26) | Final/OT | W | 6 |
| 29 | 2022-02-24 | Clemson (122) | 56 | 77 | Notre Dame (16) | Final | W | 21 |
| 30 | 2022-02-27 | Louisville (4) | 86 | 64 | Notre Dame (16) | Final | L | -22 |
| 31 | 2022-03-04 | Georgia Tech (34) | 53 | 71 | Notre Dame (17) | Final | W | 18 |
| 32 | 2022-03-05 | Miami (53) | 57 | 54 | Notre Dame (17) | Final | L | -3 |
| 33 | 2022-03-19 | Massachusetts (41) | 78 | 89 | Notre Dame (21) | Final | W | 11 |
| 34 | 2022-03-21 | Notre Dame (21) | 108 | 64 | Oklahoma (15) | Final | W | 44 |
| 35 | 2022-03-26 | Notre Dame (21) | 63 | 66 | North Carolina State (2) | Final | L | -3 |