NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Manchester | 35 | 102 | Purdue Fort Wayne (338) | Final | W | 67 |
| 2 | 2021-11-12 | Purdue Fort Wayne (148) | 0 | 0 | Ball State (69) | Cancelled | - | - |
| 3 | 2021-11-18 | Illinois-Chicago (201) | 63 | 69 | Purdue Fort Wayne (148) | Final | W | 6 |
| 4 | 2021-11-20 | IUPUI (119) | 0 | 0 | Purdue Fort Wayne (131) | Forfeit | - | - |
| 5 | 2021-11-24 | Evansville (121) | 84 | 71 | Purdue Fort Wayne (102) | Final | L | -13 |
| 6 | 2021-11-28 | Purdue Fort Wayne (102) | 56 | 68 | SIU-Edwardsville (197) | Final | L | -12 |
| 7 | 2021-12-02 | Purdue Fort Wayne (215) | 58 | 86 | Ball State (144) | Final | L | -28 |
| 8 | 2021-12-03 | Purdue Fort Wayne (215) | 0 | 0 | Wright State (341) | Forfeit | - | - |
| 9 | 2021-12-05 | Purdue Fort Wayne (215) | 60 | 69 | Northern Kentucky (136) | Final | L | -9 |
| 10 | 2021-12-09 | Purdue Fort Wayne (280) | 51 | 68 | Southeast Missouri State (307) | Final | L | -17 |
| 11 | 2021-12-12 | Purdue Fort Wayne (280) | 41 | 78 | Notre Dame (19) | Final | L | -37 |
| 12 | 2021-12-20 | Indiana State (243) | 55 | 53 | Purdue Fort Wayne (306) | Final | L | -2 |
| 13 | 2021-12-30 | Purdue Fort Wayne (318) | 41 | 64 | Youngstown State (118) | Final | L | -23 |
| 14 | 2022-01-01 | Purdue Fort Wayne (318) | 48 | 52 | Robert Morris (312) | Final | L | -4 |
| 15 | 2022-01-06 | Oakland (204) | 63 | 60 | Purdue Fort Wayne (330) | Final | L | -3 |
| 16 | 2022-01-08 | Detroit (320) | 57 | 62 | Purdue Fort Wayne (148) | Final | W | 5 |
| 17 | 2022-01-14 | Purdue Fort Wayne (327) | 56 | 68 | Milwaukee (243) | Final | L | -12 |
| 18 | 2022-01-16 | Purdue Fort Wayne (148) | 0 | 0 | Green Bay (89) | Canceled | - | - |
| 19 | 2022-01-20 | Purdue Fort Wayne (332) | 59 | 85 | Cleveland State (165) | Final | L | -26 |
| 20 | 2022-01-22 | Cleveland State (165) | 80 | 58 | Purdue Fort Wayne (332) | Final | L | -22 |
| 21 | 2022-01-27 | Purdue Fort Wayne (148) | 55 | 74 | IU-Indy (247) | Final | L | -19 |
| 22 | 2022-01-29 | Purdue Fort Wayne (333) | 88 | 61 | Illinois-Chicago (337) | Final | W | 27 |
| 23 | 2022-02-03 | Northern Kentucky (122) | 67 | 43 | Purdue Fort Wayne (326) | Final | L | -24 |
| 24 | 2022-02-05 | Wright State (299) | 58 | 83 | Purdue Fort Wayne (148) | Final | W | 25 |
| 25 | 2022-02-07 | Taylor | 61 | 72 | Purdue Fort Wayne (148) | Final | W | 11 |
| 26 | 2022-02-11 | Robert Morris (267) | 60 | 48 | Purdue Fort Wayne (324) | Final | L | -12 |
| 27 | 2022-02-13 | Youngstown State (114) | 69 | 55 | Purdue Fort Wayne (324) | Final | L | -14 |
| 28 | 2022-02-17 | Purdue Fort Wayne (326) | 77 | 62 | Detroit (351) | Final | W | 15 |
| 29 | 2022-02-19 | Purdue Fort Wayne (326) | 54 | 58 | Oakland (221) | Final | L | -4 |
| 30 | 2022-02-24 | Green Bay (103) | 73 | 57 | Purdue Fort Wayne (323) | Final | L | -16 |
| 31 | 2022-02-26 | Milwaukee (205) | 53 | 51 | Purdue Fort Wayne (323) | Final | L | -2 |
| 32 | 2022-03-01 | Purdue Fort Wayne (326) | 56 | 70 | Robert Morris (252) | Final | L | -14 |