NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-12 | Louisville (13) | 59 | 61 | Arizona (123) | Final/OT | L | -2 |
| 2 | 2021-11-16 | Bellarmine (253) | 25 | 82 | Louisville (219) | Final | W | 57 |
| 3 | 2021-11-17 | Tennessee-Martin (110) | 30 | 62 | Louisville (219) | Final | W | 32 |
| 4 | 2021-11-20 | Louisville (219) | 61 | 53 | Washington (45) | Final | W | 8 |
| 5 | 2021-11-23 | Louisville (13) | 72 | 32 | Cal Poly (350) | Final | W | 40 |
| 6 | 2021-11-28 | Louisville (38) | 71 | 56 | Colorado State (72) | Final | W | 15 |
| 7 | 2021-12-02 | Michigan (10) | 48 | 70 | Louisville (29) | Final | W | 22 |
| 8 | 2021-12-05 | Belmont (120) | 66 | 80 | Louisville (29) | Final | W | 14 |
| 9 | 2021-12-12 | Kentucky (49) | 58 | 64 | Louisville (11) | Final | W | 6 |
| 10 | 2021-12-14 | Bellarmine | Louisville | Cancelled | - | - | ||
| 11 | 2021-12-16 | Eastern Kentucky (295) | 38 | 82 | Louisville (8) | Final | W | 44 |
| 12 | 2021-12-19 | Louisville (13) | 69 | 64 | Connecticut (2) | Final | W | 5 |
| 13 | 2021-12-30 | Boston College (54) | 49 | 79 | Louisville (7) | Final | W | 30 |
| 14 | 2022-01-02 | Louisville (13) | 50 | 48 | Georgia Tech (93) | Final | W | 2 |
| 15 | 2022-01-06 | Pittsburgh (64) | 39 | 81 | Louisville (6) | Final | W | 42 |
| 16 | 2022-01-13 | Syracuse (34) | 71 | 84 | Louisville (13) | Final | W | 13 |
| 17 | 2022-01-16 | Louisville (13) | 63 | 53 | Boston College (259) | Final | W | 10 |
| 18 | 2022-01-20 | Louisville (5) | 59 | 68 | North Carolina State (2) | Final | L | -9 |
| 19 | 2022-01-23 | Wake Forest (154) | 60 | 72 | Louisville (13) | Final | W | 12 |
| 20 | 2022-01-27 | Florida State (129) | 62 | 75 | Louisville (13) | Final | W | 13 |
| 21 | 2022-01-30 | Duke (27) | 65 | 77 | Louisville (5) | Final | W | 12 |
| 22 | 2022-02-01 | Louisville (5) | 69 | 66 | Miami (64) | Final | W | 3 |
| 23 | 2022-02-03 | Louisville (5) | 93 | 71 | Clemson (133) | Final | W | 22 |
| 24 | 2022-02-06 | Louisville (5) | 100 | 64 | Syracuse (89) | Final | W | 36 |
| 25 | 2022-02-10 | Virginia (38) | 0 | 2 | Louisville (13) | Forfeit | W | 2 |
| 26 | 2022-02-13 | Notre Dame (18) | 47 | 73 | Louisville (4) | Final | W | 26 |
| 27 | 2022-02-17 | Louisville (4) | 65 | 66 | North Carolina (14) | Final | L | -1 |
| 28 | 2022-02-20 | Virginia Tech (22) | 56 | 70 | Louisville (4) | Final | W | 14 |
| 29 | 2022-02-24 | Louisville (4) | 66 | 55 | Pittsburgh (108) | Final | W | 11 |
| 30 | 2022-02-27 | Louisville (4) | 86 | 64 | Notre Dame (16) | Final | W | 22 |
| 31 | 2022-03-04 | Miami (53) | 61 | 59 | Louisville (4) | Final | L | -2 |
| 32 | 2022-03-18 | Albany (175) | 51 | 83 | Louisville (5) | Final | W | 32 |
| 33 | 2022-03-20 | Gonzaga (27) | 59 | 68 | Louisville (5) | Final | W | 9 |
| 34 | 2022-03-26 | Tennessee (10) | 64 | 76 | Louisville (5) | Final | W | 12 |
| 35 | 2022-03-28 | Michigan (17) | 50 | 62 | Louisville (5) | Final | W | 12 |
| 36 | 2022-04-01 | Louisville (5) | 59 | 72 | South Carolina (1) | Final | L | -13 |