NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Central Connecticut State (305) | 50 | 87 | Massachusetts (86) | Final | W | 37 |
| 2 | 2021-11-12 | Harvard (66) | 71 | 80 | Massachusetts (95) | Final | W | 9 |
| 3 | 2021-11-16 | Iona (90) | 56 | 79 | Massachusetts (54) | Final | W | 23 |
| 4 | 2021-11-19 | Massachusetts (54) | 61 | 58 | Holy Cross (319) | Final | W | 3 |
| 5 | 2021-11-23 | Massachusetts (95) | 80 | 62 | Providence (147) | Final | W | 18 |
| 6 | 2021-11-26 | Massachusetts (95) | 81 | 63 | South Dakota State (42) | Final | W | 18 |
| 7 | 2021-11-27 | Kent State (75) | 64 | 72 | Massachusetts (45) | Final | W | 8 |
| 8 | 2021-11-28 | Iowa State (36) | 76 | 71 | Massachusetts (45) | Final | L | -5 |
| 9 | 2021-12-01 | Fairfield (156) | 61 | 74 | Massachusetts (31) | Final | W | 13 |
| 10 | 2021-12-05 | UMass-Lowell (251) | 53 | 58 | Massachusetts (31) | Final | W | 5 |
| 11 | 2021-12-08 | Boston College (76) | 66 | 60 | Massachusetts (31) | Final | L | -6 |
| 12 | 2021-12-11 | Massachusetts (31) | 87 | 75 | Columbia (57) | Final | W | 12 |
| 13 | 2021-12-19 | Vermont (85) | 63 | 68 | Massachusetts (95) | Final | W | 5 |
| 14 | 2021-12-22 | Massachusetts (36) | 86 | 40 | Hartford (352) | Final | W | 46 |
| 15 | 2021-12-28 | Massachusetts (95) | 0 | 0 | Dartmouth (287) | Postponed | - | - |
| 16 | 2022-01-01 | George Mason (204) | 0 | 0 | Massachusetts (36) | Postponed | - | - |
| 17 | 2022-01-05 | Massachusetts (95) | 0 | 0 | Rhode Island (41) | Postponed | - | - |
| 18 | 2022-01-09 | La Salle | Massachusetts | Postponed | - | - | ||
| 19 | 2022-01-12 | Massachusetts (95) | 72 | 60 | Virginia Commonwealth (235) | Final | W | 12 |
| 20 | 2022-01-15 | Massachusetts (38) | 73 | 72 | Richmond (111) | Final/OT | W | 1 |
| 21 | 2022-01-17 | Massachusetts (38) | 58 | 66 | Rhode Island (71) | Final | L | -8 |
| 22 | 2022-01-19 | Dayton (141) | 69 | 60 | Massachusetts (95) | Final | L | -9 |
| 23 | 2022-01-22 | Massachusetts (43) | 68 | 41 | George Washington (172) | Final | W | 27 |
| 24 | 2022-01-26 | Rhode Island (48) | 60 | 46 | Massachusetts (46) | Final | L | -14 |
| 25 | 2022-01-29 | Massachusetts (46) | 74 | 48 | Saint Joseph's (175) | Final | W | 26 |
| 26 | 2022-02-05 | Saint Louis (206) | 66 | 69 | Massachusetts (95) | Final | W | 3 |
| 27 | 2022-02-09 | Massachusetts (95) | 78 | 59 | St. Bonaventure (195) | Final | W | 19 |
| 28 | 2022-02-11 | George Mason (224) | 58 | 87 | Massachusetts (50) | Final | W | 29 |
| 29 | 2022-02-13 | Duquesne (180) | 59 | 89 | Massachusetts (50) | Final | W | 30 |
| 30 | 2022-02-16 | Fordham (261) | 57 | 60 | Massachusetts (95) | Final | W | 3 |
| 31 | 2022-02-20 | Massachusetts (44) | 67 | 76 | Davidson (131) | Final | L | -9 |
| 32 | 2022-02-23 | Virginia Commonwealth (80) | 57 | 66 | Massachusetts (49) | Final | W | 9 |
| 33 | 2022-02-26 | Massachusetts (49) | 74 | 62 | Saint Louis (196) | Final | W | 12 |
| 34 | 2022-03-04 | Fordham (69) | 63 | 66 | Massachusetts (49) | Final | W | 3 |
| 35 | 2022-03-05 | Saint Joseph's (165) | 58 | 76 | Massachusetts (49) | Final | W | 18 |
| 36 | 2022-03-06 | Massachusetts (49) | 62 | 56 | Dayton (35) | Final | W | 6 |
| 37 | 2022-03-19 | Massachusetts (41) | 78 | 89 | Notre Dame (21) | Final | L | -11 |