NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Wake Forest (48) | 68 | 55 | Mercer (118) | Final | W | 13 |
| 2 | 2021-11-12 | Cornell (268) | 42 | 64 | Wake Forest (154) | Final | W | 22 |
| 3 | 2021-11-14 | UNC-Greensboro (297) | 45 | 56 | Wake Forest (48) | Final | W | 11 |
| 4 | 2021-11-18 | Charlotte (167) | 49 | 55 | Wake Forest (154) | Final | W | 6 |
| 5 | 2021-11-21 | East Carolina (239) | 52 | 73 | Wake Forest (8) | Final | W | 21 |
| 6 | 2021-11-24 | Wake Forest (24) | 79 | 50 | High Point (155) | Final | W | 29 |
| 7 | 2021-11-27 | UMBC (345) | 48 | 94 | Wake Forest (24) | Final | W | 46 |
| 8 | 2021-12-01 | Nebraska (11) | 86 | 60 | Wake Forest (15) | Final | L | -26 |
| 9 | 2021-12-04 | Troy (67) | 61 | 90 | Wake Forest (154) | Final | W | 29 |
| 10 | 2021-12-13 | East Tennessee State (322) | 58 | 90 | Wake Forest (34) | Final | W | 32 |
| 11 | 2021-12-15 | South Carolina State (353) | 40 | 94 | Wake Forest (33) | Final | W | 54 |
| 12 | 2021-12-19 | Wake Forest (154) | 45 | 62 | Georgia Tech (93) | Final | L | -17 |
| 13 | 2021-12-30 | Florida State (112) | 69 | 75 | Wake Forest (47) | Final/OT | W | 6 |
| 14 | 2022-01-02 | Virginia Tech (39) | 66 | 53 | Wake Forest (154) | Final | L | -13 |
| 15 | 2022-01-06 | Wake Forest (52) | 47 | 46 | Miami (82) | Final | W | 1 |
| 16 | 2022-01-09 | Wake Forest (154) | 46 | 87 | Florida State (129) | Final | L | -41 |
| 17 | 2022-01-13 | Notre Dame (20) | 74 | 64 | Wake Forest (154) | Final | L | -10 |
| 18 | 2022-01-16 | Wake Forest (154) | 57 | 65 | Pittsburgh (279) | Final | L | -8 |
| 19 | 2022-01-20 | Clemson (133) | 66 | 44 | Wake Forest (76) | Final | L | -22 |
| 20 | 2022-01-23 | Wake Forest (154) | 60 | 72 | Louisville (13) | Final | L | -12 |
| 21 | 2022-01-27 | Miami (64) | 66 | 59 | Wake Forest (154) | Final | L | -7 |
| 22 | 2022-02-03 | North Carolina (13) | 78 | 59 | Wake Forest (88) | Final | L | -19 |
| 23 | 2022-02-06 | Wake Forest (88) | 76 | 81 | Duke (34) | Final | L | -5 |
| 24 | 2022-02-10 | Wake Forest (154) | 78 | 87 | Clemson (47) | Final | L | -9 |
| 25 | 2022-02-13 | Virginia (230) | 53 | 68 | Wake Forest (91) | Final | W | 15 |
| 26 | 2022-02-17 | Wake Forest (95) | 61 | 92 | North Carolina State (2) | Final | L | -31 |
| 27 | 2022-02-20 | Wake Forest (95) | 70 | 82 | Boston College (51) | Final | L | -12 |
| 28 | 2022-02-24 | Syracuse (104) | 60 | 76 | Wake Forest (96) | Final | W | 16 |
| 29 | 2022-02-27 | Georgia Tech (32) | 64 | 56 | Wake Forest (96) | Final | L | -8 |
| 30 | 2022-03-02 | Virginia (190) | 53 | 61 | Wake Forest (90) | Final | W | 8 |
| 31 | 2022-03-03 | Wake Forest (90) | 40 | 45 | Georgia Tech (34) | Final | L | -5 |
| 32 | 2022-03-17 | Akron (130) | 59 | 71 | Wake Forest (90) | Final | W | 12 |
| 33 | 2022-03-21 | Wake Forest (90) | 55 | 67 | Middle Tennessee (71) | Final | L | -12 |