NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Texas Southern (288) | 71 | 114 | DePaul (52) | Final | W | 43 |
| 2 | 2021-11-12 | Loyola-Chicago (175) | 53 | 87 | DePaul (229) | Final | W | 34 |
| 3 | 2021-11-15 | DePaul (52) | 75 | 95 | Texas A&M (4) | Final | L | -20 |
| 4 | 2021-11-21 | Northwestern (41) | 75 | 78 | DePaul (61) | Final | W | 3 |
| 5 | 2021-11-25 | DePaul (229) | 77 | 74 | Rutgers (158) | Final | W | 3 |
| 6 | 2021-11-26 | Arizona (123) | 75 | 68 | DePaul (229) | Final | L | -7 |
| 7 | 2021-11-27 | Vanderbilt (124) | 74 | 91 | DePaul (48) | Final | W | 17 |
| 8 | 2021-12-03 | Butler (330) | 64 | 101 | DePaul (42) | Final | W | 37 |
| 9 | 2021-12-05 | Xavier (217) | 85 | 103 | DePaul (42) | Final | W | 18 |
| 10 | 2021-12-09 | DePaul (39) | 94 | 85 | Kentucky (49) | Final | W | 9 |
| 11 | 2021-12-14 | Nicholls State (340) | 72 | 100 | DePaul (33) | Final | W | 28 |
| 12 | 2021-12-16 | Northern Illinois (223) | 71 | 103 | DePaul (34) | Final | W | 32 |
| 13 | 2021-12-19 | DePaul (229) | 107 | 93 | St. John's (87) | Final | W | 14 |
| 14 | 2021-12-22 | Notre Dame (16) | 91 | 86 | DePaul (26) | Final | L | -5 |
| 15 | 2021-12-31 | Connecticut (2) | 0 | 0 | DePaul (229) | Postponed | - | - |
| 16 | 2022-01-07 | DePaul (34) | 98 | 77 | Providence (143) | Final | W | 21 |
| 17 | 2022-01-12 | DePaul (229) | 85 | 88 | Marquette (83) | Final/OT | L | -3 |
| 18 | 2022-01-14 | Villanova (102) | 63 | 75 | DePaul (34) | Final | W | 12 |
| 19 | 2022-01-16 | Georgetown (119) | 69 | 102 | DePaul (229) | Final | W | 33 |
| 20 | 2022-01-21 | DePaul (40) | 103 | 69 | Butler (326) | Final | W | 34 |
| 21 | 2022-01-23 | DePaul (229) | 94 | 74 | Xavier (190) | Final | W | 20 |
| 22 | 2022-01-26 | Connecticut (17) | 80 | 78 | DePaul (39) | Final | L | -2 |
| 23 | 2022-01-28 | St. John's (169) | 88 | 94 | DePaul (39) | Final | W | 6 |
| 24 | 2022-01-30 | DePaul (39) | 85 | 65 | Seton Hall (95) | Final | W | 20 |
| 25 | 2022-02-04 | Creighton (38) | 77 | 68 | DePaul (40) | Final | L | -9 |
| 26 | 2022-02-06 | Providence (142) | 67 | 88 | DePaul (40) | Final | W | 21 |
| 27 | 2022-02-11 | DePaul (40) | 60 | 84 | Connecticut (9) | Final | L | -24 |
| 28 | 2022-02-13 | DePaul (40) | 105 | 104 | Georgetown (232) | Final/2OT | W | 1 |
| 29 | 2022-02-16 | Marquette (83) | 66 | 77 | DePaul (229) | Final | W | 11 |
| 30 | 2022-02-20 | DePaul (43) | 64 | 73 | Villanova (56) | Final | L | -9 |
| 31 | 2022-02-25 | Seton Hall (70) | 94 | 90 | DePaul (229) | Final | L | -4 |
| 32 | 2022-02-27 | DePaul (44) | 90 | 84 | Creighton (37) | Final | W | 6 |
| 33 | 2022-03-05 | Marquette (68) | 105 | 85 | DePaul (44) | Final | L | -20 |
| 34 | 2022-03-16 | DePaul (45) | 57 | 88 | Dayton (40) | Final | L | -31 |