NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Davidson (218) | 57 | 76 | Virginia Tech (36) | Final | W | 19 |
| 2 | 2021-11-11 | Virginia Tech (39) | 75 | 38 | George Washington (160) | Final | W | 37 |
| 3 | 2021-11-14 | Virginia Tech (36) | 81 | 52 | George Mason (312) | Final | W | 29 |
| 4 | 2021-11-17 | Coppin State (94) | 32 | 85 | Virginia Tech (2) | Final | W | 53 |
| 5 | 2021-11-20 | Campbell (243) | 39 | 84 | Virginia Tech (2) | Final | W | 45 |
| 6 | 2021-11-26 | Virginia Tech (39) | 68 | 76 | Missouri State (110) | Final | L | -8 |
| 7 | 2021-11-27 | Virginia Tech (2) | 54 | 49 | Tennessee-Martin (145) | Final | W | 5 |
| 8 | 2021-12-01 | Virginia Tech (20) | 70 | 60 | Wisconsin (313) | Final | W | 10 |
| 9 | 2021-12-05 | Tennessee (3) | 64 | 58 | Virginia Tech (20) | Final | L | -6 |
| 10 | 2021-12-07 | Virginia Tech (29) | 40 | 59 | Liberty (81) | Final | L | -19 |
| 11 | 2021-12-12 | Radford (239) | 40 | 89 | Virginia Tech (29) | Final | W | 49 |
| 12 | 2021-12-19 | Virginia Tech (39) | 92 | 75 | Florida State (129) | Final | W | 17 |
| 13 | 2021-12-30 | Duke (20) | 55 | 77 | Virginia Tech (37) | Final | W | 22 |
| 14 | 2022-01-02 | Virginia Tech (39) | 66 | 53 | Wake Forest (154) | Final | W | 13 |
| 15 | 2022-01-06 | Virginia (192) | 0 | 0 | Virginia Tech (24) | Postponed | - | - |
| 16 | 2022-01-09 | Virginia Tech (39) | 46 | 71 | North Carolina (14) | Final | L | -25 |
| 17 | 2022-01-13 | Virginia Tech (39) | 65 | 54 | Duke (8) | Final | W | 11 |
| 18 | 2022-01-16 | Clemson (47) | 0 | 0 | Virginia Tech (39) | Postponed | - | - |
| 19 | 2022-01-18 | Virginia (200) | 52 | 69 | Virginia Tech (25) | Final | W | 17 |
| 20 | 2022-01-20 | Pittsburgh (79) | 65 | 75 | Virginia Tech (25) | Final | W | 10 |
| 21 | 2022-01-23 | Virginia Tech (39) | 45 | 51 | North Carolina State (27) | Final | L | -6 |
| 22 | 2022-01-27 | Virginia Tech (39) | 71 | 42 | Virginia (38) | Final | W | 29 |
| 23 | 2022-02-03 | Virginia Tech (31) | 55 | 68 | Notre Dame (20) | Final | L | -13 |
| 24 | 2022-02-06 | Boston College (48) | 62 | 85 | Virginia Tech (31) | Final | W | 23 |
| 25 | 2022-02-08 | Clemson (47) | 42 | 73 | Virginia Tech (39) | Final | W | 31 |
| 26 | 2022-02-10 | Georgia Tech (93) | 63 | 73 | Virginia Tech (39) | Final | W | 10 |
| 27 | 2022-02-13 | North Carolina (12) | 61 | 66 | Virginia Tech (31) | Final | W | 5 |
| 28 | 2022-02-17 | Virginia Tech (22) | 102 | 53 | Syracuse (89) | Final | W | 49 |
| 29 | 2022-02-20 | Virginia Tech (22) | 56 | 70 | Louisville (4) | Final | L | -14 |
| 30 | 2022-02-24 | Miami (54) | 63 | 70 | Virginia Tech (21) | Final | W | 7 |
| 31 | 2022-02-27 | North Carolina State (2) | 68 | 66 | Virginia Tech (21) | Final | L | -2 |
| 32 | 2022-03-03 | Clemson (125) | 60 | 82 | Virginia Tech (22) | Final | W | 22 |
| 33 | 2022-03-04 | Virginia Tech (22) | 87 | 80 | North Carolina (10) | Final/OT | W | 7 |
| 34 | 2022-03-05 | Virginia Tech (22) | 55 | 70 | North Carolina State (2) | Final | L | -15 |
| 35 | 2022-03-18 | Florida Gulf Coast (22) | 84 | 81 | Virginia Tech (20) | Final | L | -3 |