NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Oklahoma (62) | 73 | 71 | South Dakota (45) | Final | L | -2 |
| 2 | 2021-11-12 | South Carolina (3) | 72 | 41 | South Dakota (112) | Final | L | -31 |
| 3 | 2021-11-15 | South Dakota (45) | 61 | 46 | Drake (71) | Final | W | 15 |
| 4 | 2021-11-18 | Briar Cliff | 35 | 83 | South Dakota (112) | Final | W | 48 |
| 5 | 2021-11-25 | South Dakota (112) | 57 | 73 | Northwestern (142) | Final | L | -16 |
| 6 | 2021-11-26 | Texas A&M (54) | 58 | 44 | South Dakota (112) | Final | L | -14 |
| 7 | 2021-11-27 | Pittsburgh (59) | 61 | 72 | South Dakota (126) | Final/OT | W | 11 |
| 8 | 2021-12-04 | Wichita State (266) | 59 | 71 | South Dakota (112) | Final | W | 12 |
| 9 | 2021-12-06 | Bradley (220) | 39 | 62 | South Dakota (98) | Final | W | 23 |
| 10 | 2021-12-10 | Valparaiso (347) | 31 | 51 | South Dakota (74) | Final | W | 20 |
| 11 | 2021-12-16 | South Dakota (72) | 73 | 71 | Creighton (40) | Final | W | 2 |
| 12 | 2021-12-20 | South Dakota (72) | 90 | 59 | Oral Roberts (170) | Final | W | 31 |
| 13 | 2021-12-22 | South Dakota (47) | 67 | 57 | UMKC (82) | Final | W | 10 |
| 14 | 2021-12-30 | North Dakota (256) | 46 | 85 | South Dakota (38) | Final | W | 39 |
| 15 | 2022-01-01 | North Dakota State (190) | 38 | 65 | South Dakota (38) | Final | W | 27 |
| 16 | 2022-01-08 | South Dakota State (42) | 42 | 65 | South Dakota (112) | Final | W | 23 |
| 17 | 2022-01-13 | South Dakota (112) | 79 | 51 | Denver (269) | Final | W | 28 |
| 18 | 2022-01-15 | South Dakota (37) | 68 | 45 | Nebraska-Omaha (216) | Final | W | 23 |
| 19 | 2022-01-20 | Western Illinois (177) | 53 | 70 | South Dakota (37) | Final | W | 17 |
| 20 | 2022-01-22 | St. Thomas (292) | 43 | 70 | South Dakota (37) | Final | W | 27 |
| 21 | 2022-01-27 | South Dakota (112) | 78 | 59 | North Dakota State (59) | Final | W | 19 |
| 22 | 2022-01-29 | South Dakota (38) | 88 | 72 | North Dakota (182) | Final | W | 16 |
| 23 | 2022-02-05 | South Dakota (112) | 65 | 75 | South Dakota State (42) | Final | L | -10 |
| 24 | 2022-02-10 | Nebraska-Omaha (345) | 35 | 61 | South Dakota (112) | Final | W | 26 |
| 25 | 2022-02-12 | Denver (280) | 53 | 81 | South Dakota (47) | Final | W | 28 |
| 26 | 2022-02-17 | South Dakota (45) | 73 | 46 | St. Thomas (302) | Final | W | 27 |
| 27 | 2022-02-19 | South Dakota (45) | 0 | 0 | Western Illinois (204) | Postponed | - | - |
| 28 | 2022-02-24 | UMKC (93) | 49 | 71 | South Dakota (45) | Final | W | 22 |
| 29 | 2022-02-26 | Oral Roberts (181) | 49 | 78 | South Dakota (45) | Final | W | 29 |
| 30 | 2022-02-28 | South Dakota (45) | 75 | 48 | Western Illinois (210) | Final | W | 27 |
| 31 | 2022-03-05 | Western Illinois (223) | 49 | 75 | South Dakota (40) | Final | W | 26 |
| 32 | 2022-03-07 | UMKC (98) | 67 | 81 | South Dakota (40) | Final | W | 14 |
| 33 | 2022-03-08 | South Dakota (40) | 56 | 45 | South Dakota State (52) | Final | W | 11 |
| 34 | 2022-03-18 | South Dakota (38) | 75 | 61 | Ole Miss (19) | Final | W | 14 |
| 35 | 2022-03-20 | South Dakota (38) | 61 | 47 | Baylor (6) | Final | W | 14 |
| 36 | 2022-03-26 | South Dakota (38) | 49 | 52 | Michigan (17) | Final | L | -3 |