NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Loyola-Maryland (337) | 71 | 81 | Niagara (269) | Final | W | 10 |
| 2 | 2021-11-12 | Niagara (362) | 64 | 77 | Oakland (262) | Final | L | -13 |
| 3 | 2021-11-14 | Niagara (269) | 65 | 89 | Michigan State (40) | Final | L | -24 |
| 4 | 2021-11-17 | Colgate (224) | 65 | 74 | Niagara (226) | Final | W | 9 |
| 5 | 2021-11-20 | Niagara (226) | 71 | 83 | La Salle (190) | Final | L | -12 |
| 6 | 2021-11-23 | St. Bonaventure (195) | 0 | 0 | Niagara (362) | Cancelled | - | - |
| 7 | 2021-12-01 | Niagara (269) | 55 | 95 | Buffalo (75) | Final | L | -40 |
| 8 | 2021-12-04 | Cornell (268) | 71 | 76 | Niagara (362) | Final | W | 5 |
| 9 | 2021-12-08 | Niagara (248) | 78 | 82 | Xavier (247) | Final | L | -4 |
| 10 | 2021-12-17 | Saint Peter's (292) | 68 | 64 | Niagara (274) | Final | L | -4 |
| 11 | 2021-12-19 | Manhattan (296) | 70 | 73 | Niagara (362) | Final | W | 3 |
| 12 | 2021-12-30 | Niagara (270) | 0 | 0 | Rider (286) | Cancelled | - | - |
| 13 | 2022-01-01 | Niagara (270) | 0 | 0 | Siena (350) | Postponed | - | - |
| 14 | 2022-01-09 | Niagara (362) | 87 | 86 | Canisius (347) | Final/OT | W | 1 |
| 15 | 2022-01-13 | Fairfield (50) | 81 | 64 | Niagara (362) | Final | L | -17 |
| 16 | 2022-01-15 | Rider (285) | 92 | 70 | Niagara (256) | Final | L | -22 |
| 17 | 2022-01-18 | Niagara (281) | 75 | 74 | Rider (262) | Final | W | 1 |
| 18 | 2022-01-20 | Niagara (281) | 56 | 61 | Monmouth (185) | Final | L | -5 |
| 19 | 2022-01-22 | Niagara (281) | 65 | 72 | Marist (259) | Final | L | -7 |
| 20 | 2022-01-27 | Siena (295) | 69 | 82 | Niagara (362) | Final | W | 13 |
| 21 | 2022-01-29 | Quinnipiac (153) | 85 | 79 | Niagara (289) | Final | L | -6 |
| 22 | 2022-02-03 | Niagara (283) | 72 | 75 | Fairfield (125) | Final | L | -3 |
| 23 | 2022-02-05 | Niagara (362) | 85 | 73 | Manhattan (296) | Final | W | 12 |
| 24 | 2022-02-07 | Niagara (362) | 65 | 58 | Siena (295) | Final | W | 7 |
| 25 | 2022-02-10 | Marist (300) | 67 | 85 | Niagara (362) | Final | W | 18 |
| 26 | 2022-02-12 | Monmouth (208) | 74 | 80 | Niagara (270) | Final | W | 6 |
| 27 | 2022-02-17 | Niagara (254) | 59 | 45 | Iona (275) | Final | W | 14 |
| 28 | 2022-02-19 | Niagara (254) | 57 | 76 | Quinnipiac (153) | Final | L | -19 |
| 29 | 2022-02-24 | Niagara (254) | 68 | 74 | Saint Peter's (261) | Final | L | -6 |
| 30 | 2022-02-26 | Canisius (337) | 78 | 82 | Niagara (254) | Final | W | 4 |
| 31 | 2022-03-03 | Iona (262) | 50 | 66 | Niagara (256) | Final/OT | W | 16 |
| 32 | 2022-03-10 | Siena (290) | 59 | 60 | Niagara (251) | Final | W | 1 |
| 33 | 2022-03-11 | Niagara (251) | 38 | 75 | Fairfield (98) | Final | L | -37 |