NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Asbury | 40 | 79 | Murray State (151) | Final | W | 39 |
| 2 | 2021-11-11 | Murray State (52) | 70 | 76 | Missouri (71) | Final | L | -6 |
| 3 | 2021-11-15 | Cumberland | 56 | 94 | Murray State (151) | Final | W | 38 |
| 4 | 2021-11-19 | Murray State (223) | 78 | 55 | Chattanooga (312) | Final | W | 23 |
| 5 | 2021-11-23 | Murray State (52) | 74 | 50 | Mississippi Valley State (342) | Final | W | 24 |
| 6 | 2021-11-27 | Alabama A&M (350) | 40 | 66 | Murray State (148) | Final | W | 26 |
| 7 | 2021-11-30 | Murray State (126) | 85 | 77 | Evansville (132) | Final | W | 8 |
| 8 | 2021-12-04 | Murray State (52) | 66 | 75 | Samford (256) | Final | L | -9 |
| 9 | 2021-12-15 | North Alabama (319) | 60 | 74 | Murray State (161) | Final | W | 14 |
| 10 | 2021-12-18 | Lipscomb (286) | 50 | 74 | Murray State (52) | Final | W | 24 |
| 11 | 2021-12-21 | Murray State (137) | 51 | 67 | Florida (71) | Final | L | -16 |
| 12 | 2021-12-30 | Southeast Missouri State (302) | 58 | 82 | Murray State (153) | Final | W | 24 |
| 13 | 2022-01-01 | Tennessee Tech (185) | 65 | 62 | Murray State (153) | Final | L | -3 |
| 14 | 2022-01-08 | Murray State (52) | 70 | 45 | Tennessee Tech (222) | Final | W | 25 |
| 15 | 2022-01-08 | Murray State | SIU-Edwardsville | Postponed | - | - | ||
| 16 | 2022-01-13 | Tennessee State (322) | 62 | 76 | Murray State (52) | Final | W | 14 |
| 17 | 2022-01-15 | Murray State (158) | 52 | 67 | Belmont (101) | Final | L | -15 |
| 18 | 2022-01-17 | Murray State (158) | 80 | 71 | Eastern Illinois (233) | Final | W | 9 |
| 19 | 2022-01-20 | Eastern Illinois (253) | 71 | 64 | Murray State (142) | Final/OT | L | -7 |
| 20 | 2022-01-22 | Tennessee-Martin (216) | 49 | 65 | Murray State (142) | Final | W | 16 |
| 21 | 2022-01-24 | Murray State (142) | 84 | 82 | SIU-Edwardsville (250) | Final | W | 2 |
| 22 | 2022-01-29 | Morehead State (353) | 44 | 79 | Murray State (141) | Final | W | 35 |
| 23 | 2022-02-03 | Murray State (138) | 67 | 69 | Austin Peay (182) | Final/OT | L | -2 |
| 24 | 2022-02-05 | SIU-Edwardsville (242) | 73 | 87 | Murray State (52) | Final | W | 14 |
| 25 | 2022-02-10 | Murray State (52) | 79 | 53 | Tennessee State (322) | Final | W | 26 |
| 26 | 2022-02-12 | Murray State (142) | 72 | 58 | Morehead State (354) | Final | W | 14 |
| 27 | 2022-02-16 | Austin Peay (177) | 61 | 68 | Murray State (52) | Final/OT | W | 7 |
| 28 | 2022-02-19 | Murray State (135) | 69 | 56 | Tennessee-Martin (201) | Final | W | 13 |
| 29 | 2022-02-24 | Belmont (79) | 85 | 79 | Murray State (125) | Final | L | -6 |
| 30 | 2022-02-26 | Murray State (125) | 86 | 54 | Southeast Missouri State (329) | Final | W | 32 |
| 31 | 2022-03-03 | SIU-Edwardsville (255) | 76 | 84 | Murray State (131) | Final | W | 8 |
| 32 | 2022-03-04 | Murray State (131) | 62 | 68 | Tennessee Tech (142) | Final | L | -6 |
| 33 | 2022-03-17 | Murray State (134) | 47 | 73 | Vanderbilt (81) | Final | L | -26 |