NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | SIU-Edwardsville (316) | 62 | 98 | Kansas (153) | Final | L | -36 |
| 2 | 2021-11-14 | SIU-Edwardsville (316) | 58 | 89 | Memphis (249) | Final | L | -31 |
| 3 | 2021-11-18 | SIU-Edwardsville (242) | 71 | 62 | Illinois (29) | Final | W | 9 |
| 4 | 2021-11-23 | SIU-Edwardsville (242) | 87 | 74 | Butler (157) | Final | W | 13 |
| 5 | 2021-11-28 | Purdue Fort Wayne (102) | 56 | 68 | SIU-Edwardsville (197) | Final | W | 12 |
| 6 | 2021-12-02 | SIU-Edwardsville (142) | 46 | 79 | Missouri (16) | Final | L | -33 |
| 7 | 2021-12-07 | Western Illinois (114) | 96 | 93 | SIU-Edwardsville (169) | Final | L | -3 |
| 8 | 2021-12-09 | Saint Louis (154) | 57 | 63 | SIU-Edwardsville (169) | Final | W | 6 |
| 9 | 2021-12-11 | Illinois State (298) | 80 | 71 | SIU-Edwardsville (169) | Final | L | -9 |
| 10 | 2021-12-19 | Toledo (166) | 66 | 57 | SIU-Edwardsville (242) | Final | L | -9 |
| 11 | 2021-12-22 | Arkansas State (239) | 74 | 71 | SIU-Edwardsville (227) | Final | L | -3 |
| 12 | 2021-12-30 | Belmont (120) | 87 | 49 | SIU-Edwardsville (238) | Final | L | -38 |
| 13 | 2022-01-01 | SIU-Edwardsville (238) | 62 | 58 | Tennessee-Martin (211) | Final | W | 4 |
| 14 | 2022-01-06 | SIU-Edwardsville (232) | 0 | 0 | Austin Peay (205) | Postponed | - | - |
| 15 | 2022-01-08 | Murray State | SIU-Edwardsville | Postponed | - | - | ||
| 16 | 2022-01-13 | SIU-Edwardsville (242) | 0 | 0 | Eastern Illinois (329) | Postponed | - | - |
| 17 | 2022-01-15 | Southeast Missouri State (321) | 66 | 73 | SIU-Edwardsville (235) | Final | W | 7 |
| 18 | 2022-01-17 | SIU-Edwardsville (235) | 55 | 76 | Austin Peay (206) | Final | L | -21 |
| 19 | 2022-01-20 | SIU-Edwardsville (250) | 60 | 75 | Tennessee Tech (182) | Final | L | -15 |
| 20 | 2022-01-22 | SIU-Edwardsville (250) | 77 | 52 | Morehead State (353) | Final | W | 25 |
| 21 | 2022-01-24 | Murray State (142) | 84 | 82 | SIU-Edwardsville (250) | Final | L | -2 |
| 22 | 2022-01-27 | Tennessee State (322) | 72 | 79 | SIU-Edwardsville (242) | Final | W | 7 |
| 23 | 2022-01-29 | SIU-Edwardsville (252) | 69 | 61 | Southeast Missouri State (331) | Final | W | 8 |
| 24 | 2022-01-31 | SIU-Edwardsville (242) | 65 | 89 | Eastern Illinois (329) | Final | L | -24 |
| 25 | 2022-02-03 | Eastern Illinois (196) | 0 | 0 | SIU-Edwardsville (253) | Postponed | - | - |
| 26 | 2022-02-05 | SIU-Edwardsville (242) | 73 | 87 | Murray State (52) | Final | L | -14 |
| 27 | 2022-02-07 | Eastern Illinois (329) | 70 | 68 | SIU-Edwardsville (242) | Final | L | -2 |
| 28 | 2022-02-10 | Tennessee-Martin (249) | 67 | 62 | SIU-Edwardsville (242) | Final | L | -5 |
| 29 | 2022-02-12 | Tennessee Tech (148) | 68 | 64 | SIU-Edwardsville (256) | Final | L | -4 |
| 30 | 2022-02-17 | SIU-Edwardsville (266) | 86 | 76 | Tennessee State (259) | Final | W | 10 |
| 31 | 2022-02-19 | SIU-Edwardsville (266) | 50 | 88 | Belmont (84) | Final | L | -38 |
| 32 | 2022-02-24 | Austin Peay (173) | 61 | 71 | SIU-Edwardsville (262) | Final | W | 10 |
| 33 | 2022-02-26 | Morehead State (354) | 77 | 94 | SIU-Edwardsville (262) | Final | W | 17 |
| 34 | 2022-03-02 | SIU-Edwardsville (255) | 86 | 84 | Tennessee-Martin (210) | Final | W | 2 |
| 35 | 2022-03-03 | SIU-Edwardsville (255) | 76 | 84 | Murray State (131) | Final | L | -8 |