Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Morehead State | 10 | James Madison | 68 | Final | W | 58 |
| 2 | 2021-09-11 | Maine | 7 | James Madison | 55 | Final | W | 48 |
| 3 | 2021-09-18 | James Madison | 37 | Weber State | 24 | Final | W | 13 |
| 4 | 2021-10-02 | James Madison | 23 | New Hampshire | 21 | Final | W | 2 |
| 5 | 2021-10-09 | Villanova | 28 | James Madison | 27 | Final | L | -1 |
| 6 | 2021-10-16 | James Madison | 19 | Richmond | 3 | Final | W | 16 |
| 7 | 2021-10-23 | James Madison | 22 | Delaware | 10 | Final | W | 12 |
| 8 | 2021-10-30 | Elon | 21 | James Madison | 45 | Final | W | 24 |
| 9 | 2021-11-06 | Campbell | 14 | James Madison | 51 | Final | W | 37 |
| 10 | 2021-11-13 | James Madison | 32 | William & Mary | 22 | Final | W | 10 |
| 11 | 2021-11-20 | Towson | 10 | James Madison | 56 | Final | W | 46 |
| 12 | 2021-12-04 | Southeastern Louisiana (145) | 20 | James Madison (89) | 59 | Final | W | 39 |
| 13 | 2021-12-10 | Montana (99) | 6 | James Madison (89) | 28 | Final | W | 22 |
| 14 | 2021-12-17 | James Madison (89) | 14 | North Dakota State (86) | 20 | Final | L | -6 |