Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | William & Mary | 0 | Virginia | 43 | Final | L | -43 |
| 2 | 2021-09-11 | Lafayette | 3 | William & Mary | 24 | Final | W | 21 |
| 3 | 2021-09-18 | William & Mary | 27 | Colgate | 7 | Final | W | 20 |
| 4 | 2021-09-25 | William & Mary | 34 | Elon | 31 | Final | W | 3 |
| 5 | 2021-10-09 | Albany | 24 | William & Mary | 31 | Final | W | 7 |
| 6 | 2021-10-16 | William & Mary | 16 | Maine | 27 | Final | L | -11 |
| 7 | 2021-10-23 | Towson | 14 | William & Mary | 40 | Final | W | 26 |
| 8 | 2021-10-30 | William & Mary | 31 | Villanova | 18 | Final | W | 13 |
| 9 | 2021-11-06 | William & Mary | 3 | Delaware | 24 | Final | L | -21 |
| 10 | 2021-11-13 | James Madison | 32 | William & Mary | 22 | Final | L | -10 |
| 11 | 2021-11-20 | Richmond | 20 | William & Mary | 17 | Final | L | -3 |