Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Towson | 31 | Morgan State | 0 | Final | W | 31 |
| 2 | 2021-09-11 | Towson | 14 | New Hampshire | 26 | Final | L | -12 |
| 3 | 2021-09-18 | North Dakota State | 35 | Towson | 7 | Final | L | -28 |
| 4 | 2021-09-25 | Towson | 21 | San Diego State | 48 | Final | L | -27 |
| 5 | 2021-10-09 | Stony Brook | 14 | Towson | 21 | Final | W | 7 |
| 6 | 2021-10-16 | Rhode Island | 7 | Towson | 28 | Final | W | 21 |
| 7 | 2021-10-23 | Towson | 14 | William & Mary | 40 | Final | L | -26 |
| 8 | 2021-10-23 | Towson | 10 | North Dakota | 34 | Final | L | -24 |
| 9 | 2021-10-30 | Albany | 24 | Towson | 38 | Final | W | 14 |
| 10 | 2021-11-06 | Towson | 17 | Richmond | 28 | Final | L | -11 |
| 11 | 2021-11-13 | Elon | 37 | Towson | 14 | Final | L | -23 |
| 12 | 2021-11-20 | Towson | 10 | James Madison | 56 | Final | L | -46 |