Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Villanova | 47 | Lehigh | 3 | Final | W | 44 |
| 2 | 2021-09-11 | Bucknell | 3 | Villanova | 55 | Final | W | 52 |
| 3 | 2021-09-18 | Richmond | 27 | Villanova | 34 | Final | W | 7 |
| 4 | 2021-09-25 | Villanova | 17 | Penn State | 38 | Final | L | -21 |
| 5 | 2021-10-09 | Villanova | 28 | James Madison | 27 | Final | W | 1 |
| 6 | 2021-10-16 | Villanova | 17 | Albany | 10 | Final | W | 7 |
| 7 | 2021-10-23 | Rhode Island | 0 | Villanova | 44 | Final | W | 44 |
| 8 | 2021-10-30 | William & Mary | 31 | Villanova | 18 | Final | L | -13 |
| 9 | 2021-11-06 | Villanova | 35 | Elon | 0 | Final | W | 35 |
| 10 | 2021-11-13 | Stony Brook | 14 | Villanova | 33 | Final | W | 19 |
| 11 | 2021-11-20 | Villanova | 21 | Delaware | 13 | Final | W | 8 |
| 12 | 2021-12-03 | Holy Cross (137) | 16 | Villanova (107) | 21 | Final | W | 5 |
| 13 | 2021-12-11 | South Dakota State (116) | 35 | Villanova (107) | 21 | Final | L | -14 |