Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Morehead State | 10 | James Madison | 68 | Final | L | -58 |
| 2 | 2021-09-11 | Point University | 9 | Morehead State | 62 | Final | W | 53 |
| 3 | 2021-09-18 | Morehead State | 35 | Austin Peay | 59 | Final | L | -24 |
| 4 | 2021-10-02 | Dayton | 38 | Morehead State | 45 | Final(OT) | W | 7 |
| 5 | 2021-10-09 | Morehead State | 38 | Presbyterian | 30 | Final | W | 8 |
| 6 | 2021-10-16 | Butler | 8 | Morehead State | 31 | Final | W | 23 |
| 7 | 2021-10-23 | Morehead State | 27 | Marist | 24 | Final | W | 3 |
| 8 | 2021-10-30 | Davidson | 29 | Morehead State | 22 | Final | L | -7 |
| 9 | 2021-11-06 | Morehead State | 3 | San Diego | 10 | Final | L | -7 |
| 10 | 2021-11-13 | Stetson | 35 | Morehead State | 36 | Final | W | 1 |
| 11 | 2021-11-20 | Morehead State | 51 | Valparaiso | 38 | Final | W | 13 |