Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Albany | 6 | North Dakota State | 28 | Final | W | 22 |
| 2 | 2021-09-11 | Valparaiso | 0 | North Dakota State | 64 | Final | W | 64 |
| 3 | 2021-09-18 | North Dakota State | 35 | Towson | 7 | Final | W | 28 |
| 4 | 2021-10-02 | North Dakota State | 16 | North Dakota | 10 | Final | W | 6 |
| 5 | 2021-10-09 | Northern Iowa | 20 | North Dakota State | 34 | Final | W | 14 |
| 6 | 2021-10-16 | North Dakota State | 20 | Illinois State | 0 | Final | W | 20 |
| 7 | 2021-10-23 | Missouri State | 20 | North Dakota State | 27 | Final | W | 7 |
| 8 | 2021-10-30 | Indiana State | 2 | North Dakota State | 44 | Final | W | 42 |
| 9 | 2021-11-06 | North Dakota State | 19 | South Dakota State | 27 | Final | L | -8 |
| 10 | 2021-11-13 | North Dakota State | 49 | Youngstown State | 17 | Final | W | 32 |
| 11 | 2021-11-20 | South Dakota | 24 | North Dakota State | 52 | Final | W | 28 |
| 12 | 2021-12-04 | Southern Illinois (139) | 7 | North Dakota State (86) | 38 | Final | W | 31 |
| 13 | 2021-12-11 | East Tennessee State (105) | 3 | North Dakota State (86) | 27 | Final | W | 24 |
| 14 | 2021-12-17 | James Madison (89) | 14 | North Dakota State (86) | 20 | Final | W | 6 |
| 15 | 2022-01-08 | Montana State (96) | 10 | North Dakota State (54) | 38 | Final | W | 28 |