Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Southeastern Louisiana | 49 | North Alabama | 28 | Final | W | 21 |
| 2 | 2021-09-11 | Southeastern Louisiana | 42 | Louisiana Tech | 45 | Final | L | -3 |
| 3 | 2021-09-18 | Southeastern Louisiana | 56 | Central Connecticut State | 10 | Final | W | 46 |
| 4 | 2021-10-02 | Southeastern Louisiana | 38 | McNeese State | 35 | Final | W | 3 |
| 5 | 2021-10-09 | Southeastern Louisiana | 58 | Nicholls State | 48 | Final | W | 10 |
| 6 | 2021-10-16 | Houston Baptist | 24 | Southeastern Louisiana | 61 | Final | W | 37 |
| 7 | 2021-10-23 | Southeastern Louisiana | 51 | Northwestern State | 14 | Final | W | 37 |
| 8 | 2021-10-30 | McNeese State | 20 | Southeastern Louisiana | 23 | Final | W | 3 |
| 9 | 2021-11-06 | Southeastern Louisiana | 52 | Incarnate Word | 55 | Final | L | -3 |
| 10 | 2021-11-13 | Northwestern State | 28 | Southeastern Louisiana | 56 | Final | W | 28 |
| 11 | 2021-11-18 | Nicholls State | 45 | Southeastern Louisiana | 42 | Final | L | -3 |
| 12 | 2021-11-27 | Florida A&M (146) | 14 | Southeastern Louisiana (139) | 38 | Final | W | 24 |
| 13 | 2021-12-04 | Southeastern Louisiana (145) | 20 | James Madison (89) | 59 | Final | L | -39 |