Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Wofford | 24 | Elon | 22 | Final | L | -2 |
| 2 | 2021-09-11 | Elon | 24 | Campbell | 23 | Final | W | 1 |
| 3 | 2021-09-18 | Elon | 10 | Appalachian State | 44 | Final | L | -34 |
| 4 | 2021-09-25 | William & Mary | 34 | Elon | 31 | Final | L | -3 |
| 5 | 2021-10-02 | Elon | 20 | Richmond | 7 | Final | W | 13 |
| 6 | 2021-10-09 | Elon | 33 | Maine | 23 | Final | W | 10 |
| 7 | 2021-10-23 | New Hampshire | 10 | Elon | 24 | Final | W | 14 |
| 8 | 2021-10-30 | Elon | 21 | James Madison | 45 | Final | L | -24 |
| 9 | 2021-11-06 | Villanova | 35 | Elon | 0 | Final | L | -35 |
| 10 | 2021-11-13 | Elon | 37 | Towson | 14 | Final | W | 23 |
| 11 | 2021-11-20 | Rhode Island | 28 | Elon | 43 | Final | W | 15 |