Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Delaware | 34 | Maine | 24 | Final | W | 10 |
| 2 | 2021-09-18 | Delaware | 13 | Rutgers | 45 | Final | L | -32 |
| 3 | 2021-10-02 | Albany | 15 | Delaware | 20 | Final | W | 5 |
| 4 | 2021-10-09 | Delaware | 15 | Rhode Island | 22 | Final | L | -7 |
| 5 | 2021-10-16 | Delaware | 17 | Stony Brook | 34 | Final | L | -17 |
| 6 | 2021-10-23 | James Madison | 22 | Delaware | 10 | Final | L | -12 |
| 7 | 2021-10-30 | Dixie State | 10 | Delaware | 17 | Final | W | 7 |
| 8 | 2021-11-06 | William & Mary | 3 | Delaware | 24 | Final | W | 21 |
| 9 | 2021-11-13 | Delaware | 27 | Richmond | 51 | Final | L | -24 |
| 10 | 2021-11-20 | Villanova | 21 | Delaware | 13 | Final | L | -8 |