Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Delaware | 34 | Maine | 24 | Final | L | -10 |
| 2 | 2021-09-11 | Maine | 7 | James Madison | 55 | Final | L | -48 |
| 3 | 2021-09-18 | Merrimack | 26 | Maine | 31 | Final | W | 5 |
| 4 | 2021-09-25 | Maine | 14 | Northern Illinois | 41 | Final | L | -27 |
| 5 | 2021-10-09 | Elon | 33 | Maine | 23 | Final | L | -10 |
| 6 | 2021-10-16 | William & Mary | 16 | Maine | 27 | Final | W | 11 |
| 7 | 2021-10-23 | Maine | 19 | Albany | 16 | Final | W | 3 |
| 8 | 2021-10-30 | Maine | 45 | Rhode Island | 24 | Final | W | 21 |
| 9 | 2021-11-06 | Stony Brook | 22 | Maine | 17 | Final | L | -5 |
| 10 | 2021-11-13 | Maine | 35 | Massachusetts | 10 | Final | W | 25 |
| 11 | 2021-11-20 | Maine | 33 | New Hampshire | 20 | Final | W | 13 |