Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Grambling (187) | 3 | Arkansas State (151) | 58 | Final | L | -55 |
| 2 | 2022-09-10 | Northwestern State (231) | 21 | Grambling (187) | 47 | Final | W | 26 |
| 3 | 2022-09-17 | Grambling (207) | 24 | Jackson State (135) | 66 | Final | L | -42 |
| 4 | 2022-09-24 | Grambling (230) | 19 | Bethune-Cookman (222) | 36 | Final | L | -17 |
| 5 | 2022-10-01 | Prairie View A&M (164) | 34 | Grambling (234) | 14 | Final | L | -20 |
| 6 | 2022-10-08 | Grambling (248) | 31 | Alabama A&M (217) | 37 | Final(OT) | L | -6 |
| 7 | 2022-10-15 | Florida A&M (182) | 20 | Grambling (247) | 16 | Final | L | -4 |
| 8 | 2022-10-29 | Alcorn State (226) | 6 | Grambling (229) | 35 | Final | W | 29 |
| 9 | 2022-11-04 | Arkansas-Pine Bluff (248) | 10 | Grambling (229) | 36 | Final | W | 26 |
| 10 | 2022-11-05 | Arkansas-Pine Bluff (255) | 10 | Grambling (219) | 36 | Final | W | 26 |
| 11 | 2022-11-12 | Grambling (226) | 7 | Texas Southern (184) | 41 | Final | L | -34 |
| 12 | 2022-11-26 | Grambling (228) | 17 | Southern (175) | 34 | Final | L | -17 |