Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Bethune-Cookman (227) | 13 | Miami (41) | 70 | Final | L | -57 |
| 2 | 2022-09-10 | South Carolina State (171) | 33 | Bethune-Cookman (227) | 9 | Final | L | -24 |
| 3 | 2022-09-24 | Grambling (230) | 19 | Bethune-Cookman (222) | 36 | Final | W | 17 |
| 4 | 2022-10-01 | Bethune-Cookman (236) | 27 | Alabama A&M (224) | 35 | Final | L | -8 |
| 5 | 2022-10-08 | Bethune-Cookman (254) | 17 | Tennessee State (249) | 41 | Final | L | -24 |
| 6 | 2022-10-15 | Jackson State (130) | 48 | Bethune-Cookman (252) | 8 | Final | L | -40 |
| 7 | 2022-10-22 | Bethune-Cookman (236) | 45 | Mississippi Valley State (260) | 35 | Final | W | 10 |
| 8 | 2022-10-29 | Bethune-Cookman (239) | 48 | Prairie View A&M (173) | 58 | Final | L | -10 |
| 9 | 2022-11-05 | Alabama State (190) | 37 | Bethune-Cookman (243) | 22 | Final | L | -15 |
| 10 | 2022-11-12 | Bethune-Cookman (247) | 14 | Alcorn State (211) | 17 | Final | L | -3 |
| 11 | 2022-11-19 | Florida A&M (165) | 41 | Bethune-Cookman (248) | 20 | Final | L | -21 |