Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Northwestern State (231) | 0 | Montana (106) | 47 | Final | L | -47 |
| 2 | 2022-09-10 | Northwestern State (231) | 21 | Grambling (187) | 47 | Final | L | -26 |
| 3 | 2022-09-17 | Northwestern State (257) | 10 | Southern Miss (101) | 62 | Final | L | -52 |
| 4 | 2022-09-24 | Lamar (257) | 27 | Northwestern State (238) | 35 | Final | W | 8 |
| 5 | 2022-10-01 | Nicholls State (247) | 33 | Northwestern State (232) | 36 | Final | W | 3 |
| 6 | 2022-10-08 | Northwestern State (242) | 27 | Eastern Illinois (201) | 35 | Final | L | -8 |
| 7 | 2022-10-15 | Northwestern State (237) | 37 | Houston Christian | 10 | Final | W | 27 |
| 8 | 2022-10-22 | Southeast Missouri State (135) | 51 | Northwestern State (238) | 16 | Final | L | -35 |
| 9 | 2022-11-05 | Northwestern State (227) | 41 | Texas A&M-Commerce (202) | 14 | Final | W | 27 |
| 10 | 2022-11-12 | Northwestern State (228) | 7 | Southeastern Louisiana (151) | 23 | Final | L | -16 |
| 11 | 2022-11-19 | Incarnate Word (122) | 66 | Northwestern State (233) | 7 | Final | L | -59 |