Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Florida Memorial | 0 | Southern (232) | 86 | Final | W | 86 |
| 2 | 2022-09-10 | Southern (232) | 17 | LSU (57) | 65 | Final | L | -48 |
| 3 | 2022-09-17 | Southern (221) | 0 | Texas Southern (196) | 24 | Final | L | -24 |
| 4 | 2022-10-01 | Arkansas-Pine Bluff (240) | 3 | Southern (192) | 59 | Final | W | 56 |
| 5 | 2022-10-08 | Southern (171) | 45 | Prairie View A&M (180) | 13 | Final | W | 32 |
| 6 | 2022-10-15 | Alcorn State (201) | 17 | Southern (170) | 21 | Final | W | 4 |
| 7 | 2022-10-22 | Virginia Lynchburg | 7 | Southern (167) | 51 | Final | W | 44 |
| 8 | 2022-10-29 | Southern (174) | 0 | Jackson State (112) | 35 | Final | L | -35 |
| 9 | 2022-11-05 | Southern (177) | 16 | Florida A&M (170) | 30 | Final | L | -14 |
| 10 | 2022-11-12 | Mississippi Valley State (259) | 7 | Southern (176) | 27 | Final | W | 20 |
| 11 | 2022-11-26 | Grambling (228) | 17 | Southern (175) | 34 | Final | W | 17 |
| 12 | 2022-12-03 | Southern (181) | 24 | Jackson State (106) | 43 | Final | L | -19 |