Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Texas Southern (233) | 23 | Prairie View A&M (207) | 40 | Final | W | 17 |
| 2 | 2022-09-10 | Prairie View A&M (207) | 13 | Abilene Christian (205) | 21 | Final | L | -8 |
| 3 | 2022-09-17 | Incarnate Word (91) | 31 | Prairie View A&M (181) | 14 | Final | L | -17 |
| 4 | 2022-09-24 | Prairie View A&M (181) | 25 | Alabama State (186) | 15 | Final | W | 10 |
| 5 | 2022-09-24 | Prairie View A&M (170) | 24 | Alabama State (225) | 15 | Final | W | 9 |
| 6 | 2022-10-01 | Prairie View A&M (164) | 34 | Grambling (234) | 14 | Final | W | 20 |
| 7 | 2022-10-08 | Southern (171) | 45 | Prairie View A&M (180) | 13 | Final | L | -32 |
| 8 | 2022-10-22 | Prairie View A&M (176) | 54 | Lamar (258) | 21 | Final | W | 33 |
| 9 | 2022-10-29 | Bethune-Cookman (239) | 48 | Prairie View A&M (173) | 58 | Final | W | 10 |
| 10 | 2022-11-04 | Alcorn State (216) | 23 | Prairie View A&M (178) | 16 | Final(OT) | L | -7 |
| 11 | 2022-11-12 | Prairie View A&M (178) | 55 | Arkansas-Pine Bluff (257) | 24 | Final | W | 31 |
| 12 | 2022-11-19 | Prairie View A&M (193) | 7 | Mississippi Valley State (254) | 27 | Final | L | -20 |