Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Texas Southern (233) | 23 | Prairie View A&M (207) | 40 | Final | L | -17 |
| 2 | 2022-09-10 | Texas Southern (233) | 27 | North Texas (95) | 59 | Final | L | -32 |
| 3 | 2022-09-17 | Southern (221) | 0 | Texas Southern (196) | 24 | Final | W | 24 |
| 4 | 2022-09-24 | Texas Southern (194) | 24 | UTSA (85) | 52 | Final | L | -28 |
| 5 | 2022-10-01 | Alabama State (197) | 16 | Texas Southern (204) | 13 | Final | L | -3 |
| 6 | 2022-10-08 | Texas Southern (199) | 24 | Arkansas-Pine Bluff (243) | 17 | Final | W | 7 |
| 7 | 2022-10-22 | Texas Southern (184) | 34 | Alcorn State (215) | 27 | Final | W | 7 |
| 8 | 2022-10-29 | Lincoln (CA) | 2 | Texas Southern (190) | 37 | Final | W | 35 |
| 9 | 2022-11-05 | Jackson State (105) | 41 | Texas Southern (193) | 14 | Final | L | -27 |
| 10 | 2022-11-12 | Grambling (226) | 7 | Texas Southern (184) | 41 | Final | W | 34 |
| 11 | 2022-11-19 | Texas Southern (195) | 20 | Alabama A&M (215) | 24 | Final | L | -4 |