Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Florida A&M (146) | 24 | North Carolina (63) | 56 | Final | L | -32 |
| 2 | 2022-09-04 | Florida A&M (146) | 3 | Jackson State (126) | 59 | Final | L | -56 |
| 3 | 2022-09-10 | Albany State | 13 | Florida A&M (146) | 23 | Final | W | 10 |
| 4 | 2022-09-24 | Alabama A&M (242) | 25 | Florida A&M (204) | 38 | Final | W | 13 |
| 5 | 2022-10-01 | Mississippi Valley State (260) | 7 | Florida A&M (196) | 34 | Final | W | 27 |
| 6 | 2022-10-08 | Florida A&M (188) | 20 | South Carolina State (225) | 14 | Final | W | 6 |
| 7 | 2022-10-15 | Florida A&M (182) | 20 | Grambling (247) | 16 | Final | W | 4 |
| 8 | 2022-10-29 | Arkansas-Pine Bluff (248) | 6 | Florida A&M (177) | 27 | Final | W | 21 |
| 9 | 2022-11-05 | Southern (177) | 16 | Florida A&M (170) | 30 | Final | W | 14 |
| 10 | 2022-11-12 | Florida A&M (168) | 21 | Alabama State (196) | 14 | Final | W | 7 |
| 11 | 2022-11-19 | Florida A&M (165) | 41 | Bethune-Cookman (248) | 20 | Final | W | 21 |