Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Lane | 42 | Arkansas-Pine Bluff (250) | 48 | Final | W | 6 |
| 2 | 2022-09-10 | North American | 3 | Arkansas-Pine Bluff (250) | 76 | Final | W | 73 |
| 3 | 2022-09-17 | Arkansas-Pine Bluff (194) | 7 | Oklahoma State (26) | 63 | Final | L | -56 |
| 4 | 2022-09-24 | Arkansas-Pine Bluff (229) | 21 | Alcorn State (187) | 38 | Final | L | -17 |
| 5 | 2022-10-01 | Arkansas-Pine Bluff (240) | 3 | Southern (192) | 59 | Final | L | -56 |
| 6 | 2022-10-08 | Texas Southern (199) | 24 | Arkansas-Pine Bluff (243) | 17 | Final | L | -7 |
| 7 | 2022-10-16 | Alabama A&M (214) | 34 | Arkansas-Pine Bluff (238) | 31 | Final | L | -3 |
| 8 | 2022-10-29 | Arkansas-Pine Bluff (248) | 6 | Florida A&M (177) | 27 | Final | L | -21 |
| 9 | 2022-11-04 | Arkansas-Pine Bluff (248) | 10 | Grambling (229) | 36 | Final | L | -26 |
| 10 | 2022-11-05 | Arkansas-Pine Bluff (255) | 10 | Grambling (219) | 36 | Final | L | -26 |
| 11 | 2022-11-12 | Prairie View A&M (178) | 55 | Arkansas-Pine Bluff (257) | 24 | Final | L | -31 |
| 12 | 2022-11-24 | Arkansas-Pine Bluff (252) | 19 | Alabama State (202) | 14 | Final | W | 5 |